Yiping Chen

2 months ago | nature.com | Neil Wright |Hannah Fry |Yiping Chen |Huaidong Du |Canqing Yu |Dianjianyi Sun | +6 more

AbstractProteomics offers unique insights into human biology and drug development, but few studies have directly compared the utility of different proteomics platforms. We measured plasma levels of 2168 proteins in 3976 Chinese adults using both Olink Explore and SomaScan platforms. The correlation of protein levels between platforms was modest (median rho = 0.29), with protein abundance and data quality parameters being key factors influencing correlation.

Dec 30, 2024 | thelancet.com | Canqing Yu |Dianjianyi Sun |Pei Pei |Yiping Chen

Keywords Chronic obstructive pulmonary disease Restrictive lung function Forced expiratory volume in one second Cardiovascular disease Obesity Underweight Evidence before this study We searched PubMed for existing articles published from inception to January 19, 2024, using spirometric pattern-related terms (“COPD” OR “airflow obstruction” OR “restrictive spirometric pattern”) and outcome terms (“cardiovascular disease” OR “heart disease” OR “heart failure” OR “cerebrovascular disease” OR...

Jul 23, 2024 | nature.com | Wei Gan |Robert Clarke |Masaru Koido |Masahiro Kanai |Yukinori Okada |Yoichiro Kamatani | +7 more

AbstractElevated blood pressure (BP) is major risk factor for cardiovascular diseases (CVD). Genome-wide association studies (GWAS) conducted predominantly in populations of European ancestry have identified >2,000 BP-associated loci, but other ancestries have been less well-studied. We conducted GWAS of systolic, diastolic, pulse, and mean arterial BP in 100,453 Chinese adults. We identified 128 non-overlapping loci associated with one or more BP traits, including 74 newly-reported associations.

Mar 8, 2024 | nature.com | Dianjianyi Sun |Iona Y. Millwood |Robin G Walters |Yiping Chen |Huaidong Du |Zhengming Chen | +1 more

AbstractDespite the high prevalence of snoring in Asia, little is known about the genetic etiology of snoring and its causal relationships with cardiometabolic traits. Based on 100,626 Chinese individuals, a genome-wide association study on snoring was conducted. Four novel loci were identified for snoring traits mapped on SLC25A21, the intergenic region of WDR11 and FGFR, NAA25, ALDH2, and VTI1A, respectively.

Dec 21, 2023 | nature.com | Yuanjie Pang |Yiping Chen |Robin G Walters

AbstractType 2 diabetes (T2D) is associated with higher risk of pancreatic cancer (PC), but the underlying mechanisms are not fully understood. We conducted a case-subcohort study involving 610 PC cases and 623 subcohort participants with 92 protein biomarkers measured in baseline plasma samples.