Tricia Park

May 13, 2024 | nature.com | Alexander N Gorelick |Ignacio Vázquez-García |Marc Williams |Adam C. Weiner |Tyler Funnell |Tricia Park | +5 more

AbstractThe extent of cell-to-cell variation in tumor mitochondrial DNA (mtDNA) copy number and genotype, and the phenotypic and evolutionary consequences of such variation, are poorly characterized. Here we use amplification-free single-cell whole-genome sequencing (Direct Library Prep (DLP+)) to simultaneously assay mtDNA copy number and nuclear DNA (nuDNA) in 72,275 single cells derived from immortalized cell lines, patient-derived xenografts and primary human tumors.

Jun 19, 2023 | nature.com | Fengshen Kuo |Mustafa Buyukozkan |Tricia Park |A. Ari Hakimi |Andrew M. Intlekofer |Jan Krumsiek

AbstractTumour metabolism is controlled by coordinated changes in metabolite abundance and gene expression, but simultaneous quantification of metabolites and transcripts in primary tissue is rare. To overcome this limitation and to study gene–metabolite covariation in cancer, we assemble the Cancer Atlas of Metabolic Profiles of metabolomic and transcriptomic data from 988 tumour and control specimens spanning 11 cancer types in published and newly generated datasets.