Yujing J. Heng

Sep 13, 2024 | onlinelibrary.wiley.com | Alice Rodrigues |Yujing J. Heng |Frank J. Slack

Acaca acetyl-Coenzyme A carboxylase alpha AKT activates protein kinase B ALT alanine aminotransferases AST aspartate aminotransferases AUC Area under the curve CD81 CD81 antigen CD9 CD9 antigen CEBPA/Cebpa CCAAT enhancer binding protein alpha Cs citrate synthase Dgat1 diacylglycerol O-acyltransferase 1 EGFR Epidermal growth factor receptor EV extracellular vesicles EV-A extracellular vesicles from aged mice EV-C extracellular vesicles from young mice EV-EX extracellular vesicles from young...

Apr 15, 2024 | nature.com | Fabin Dang |Lin Wang |Wenxue Li |Felipe Batalini |Jaymin Patel |John G. Clohessy | +4 more

AbstractInduced oncoproteins degradation provides an attractive anti-cancer modality. Activation of anaphase-promoting complex (APC/CCDH1) prevents cell-cycle entry by targeting crucial mitotic proteins for degradation. Phosphorylation of its co-activator CDH1 modulates the E3 ligase activity, but little is known about its regulation after phosphorylation and how to effectively harness APC/CCDH1 activity to treat cancer.