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3 weeks ago | 
onlinelibrary.wiley.com | Lorenz Aglas |Serge A. Versteeg |Scott Smith |Line Kring Tannert
AIT allergen-specific immunotherapy AUC area-under-the-curve BPE birch pollen extract BPE-AC birch pollen extract-based active comparator EBV Epstein–Barr virus ELISA enzyme-linked immunosorbent assay FAB facilitated allergen binding FAB competition facilitated allergen binding inhibition assay FAB inhibition facilitated allergen binding inhibition assay FcεRI high-affinity IgE receptor I FcεRII CD23 GMP good manufacturing practice Ig immunoglobulin IMP investigational medicine product iMRA...
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Mar 4, 2025 | 
mdpi.com | Changqing Xia |Scott Smith |Pamela A Althof |Jeffrey J. Cannatella
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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Jul 9, 2024 | 
scholarsarchive.byu.edu | Derek Houston |David Elzinga |Peter Maughan |Scott Smith
nucleotide polymorphism, trout subspecies, genome reduction, barcoding, 454 pyro-sequencingHouston, Derek D.; Elzinga, David B.; Maughan, Peter J.; Smith, Scott M.; Kauwe, John S. K.; Evans, R. Paul; Stinger, Ryan B.; and Shiozawa, Dennis K. (2014)"Single Nucleotide Polymorphism Discovery in Cutthroat Trout Subspecies using Genome Reduction, Barcoding, and 454 Pyro-sequencing,"Journal of Undergraduate Research: Vol. 2014:Iss. 1, Article 722.
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Jun 11, 2024 | 
nature.com | Henry Cope |Jonas Elsborg |Samuel Demharter |J. McDonald |Chiara Wernecke |Sigrid S. Reinsch | +11 more
AbstractSpaceflight poses a unique set of challenges to humans and the hostile spaceflight environment can induce a wide range of increased health risks, including dermatological issues. The biology driving the frequency of skin issues in astronauts is currently not well understood.
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Jun 11, 2024 | 
nature.com | Eliah G. Overbey |JangKeun Kim |Braden T. Tierney |Jiwoon Park |Deena Najjar |Remi Klotz | +30 more
AbstractSpaceflight induces molecular, cellular, and physiological shifts in astronauts and poses myriad biomedical challenges to the human body, which are becoming increasingly relevant as more humans venture into space1-6. Yet, current frameworks for aerospace medicine are nascent and lag far behind advancements in precision medicine on Earth, underscoring the need for rapid development of space medicine databases, tools, and protocols.
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Jun 10, 2024 | 
nature.com | Keith Siew |Charlotte Nelson |Alessandra Grillo |Eliah G. Overbey |JangKeun Kim |Sanghee Yun | +41 more
AbstractMissions into Deep Space are planned this decade. Yet the health consequences of exposure to microgravity and galactic cosmic radiation (GCR) over years-long missions on indispensable visceral organs such as the kidney are largely unexplored.
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Jun 10, 2024 | 
nature.com | JangKeun Kim |Christopher R Chin |Tammy Liu |Irina Matei |Cem Meydan |Masafumi Muratani | +7 more
AbstractIt is now widely recognised that the environment in space activates a diverse set of genes involved in regulating fundamental cellular pathways. This includes the activation of genes associated with blood homeostasis and erythropoiesis, with a particular emphasis on those involved in globin chain production.
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Jun 10, 2024 | nature.com | Keith Siew |Charlotte Nelson |Alessandra Grillo |Eliah G. Overbey |JangKeun Kim |Sanghee Yun | +41 more
AbstractMissions into Deep Space are planned this decade. Yet the health consequences of exposure to microgravity and galactic cosmic radiation (GCR) over years-long missions on indispensable visceral organs such as the kidney are largely unexplored.
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Jun 10, 2024 | 
nature.com | JangKeun Kim |Braden T. Tierney |Eliah G. Overbey |Ezequiel Dantas |Jiwoon Park |Fei Wu | +16 more
AbstractSpaceflight induces an immune response in astronauts. To better characterize this effect, we generated single-cell, multi-ome, cell-free RNA (cfRNA), biochemical, and hematology data for the SpaceX Inspiration4 (I4) mission crew. We found that 18 cytokines/chemokines related to inflammation, aging, and muscle homeostasis changed after spaceflight.
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Mar 13, 2024 | 
sciencedirect.com | Scott Smith |Makoto Hoshino |Kengo Kubota
One of the functions of the skin is to serve as a physical barrier. It keeps water in the body and prevents entry of foreign material, including chemicals, pathogens, allergens, and toxins, into the body. To perform this function, the skin comprises a unique outer layer called the stratum corneum, which consists of densely packed dead cells called corneocytes (Fig 1, A). The corneocytes are rich in proteins and are dispersed in a lipid-rich phase.
