Yeeun Ahn

Sep 30, 2024 | nature.com | Soyeon Kim |Jaeyoung Kim |Yeeun Ahn |Injeong Shim |Chamlee Cho |Patrick T. Ellinor | +2 more

AbstractMetabolic syndrome (MetS) is a complex hereditary condition comprising various metabolic traits as risk factors. Although the genetics of individual MetS components have been investigated actively through large-scale genome-wide association studies, the conjoint genetic architecture has not been fully elucidated. Here, we performed the largest multivariate genome-wide association study of MetS in Europe (nobserved = 4,947,860) by leveraging genetic correlation between MetS components.

Jan 4, 2024 | nature.com | Tzu-Ting Chen |Jaeyoung Kim |Max Lam |Sang-Hyuk Jung |Soyeon Kim |Injeong Shim | +9 more

AbstractEducational attainment (EduYears), a heritable trait often used as a proxy for cognitive ability, is associated with various health and social outcomes. Previous genome-wide association studies (GWASs) on EduYears have been focused on samples of European (EUR) genetic ancestries. Here we present the first large-scale GWAS of EduYears in people of East Asian (EAS) ancestry (n = 176,400) and conduct a cross-ancestry meta-analysis with EduYears GWAS in people of EUR ancestry (n = 766,345).

May 31, 2023 | nature.com | Joohyun Yoon |Jinho Kim |Ole A. Andreassen |Yeeun Ahn

UK BiobankThe UK Biobank is a nationwide cohort of approximately 500,000 individuals aged between 40 and 69 years at the time of recruitment. Individuals were recruited during a four-year baseline period (from 2006 to 2010) at multiple centers located in the UK. The collected data include computer-assisted interviews, touchscreen-based self-report questionnaires, physical health measures, and biological samples (including genotype data).