Institut Paoli-Calmettes

Nov 6, 2024 | bmcpublichealth.biomedcentral.com | Aix Marseille Univ |Institut Paoli-Calmettes |Université de Nantes |Le Kremlin-Bicêtre

Our pooled sample comprised 4 025 respondents. Half were women and half had tertiary education. The mean age was 49 years (SD = 17.3) and the mean financial deprivation score was 38.9 (SD = 22.9). A statistically significant difference in socio-demographic characteristics was observed between the two studies we analyzed (i.e., HLS19 and SLAVACO) (Table 1). Furthermore, the average HLS19-Q12 score was higher than the average HLS19-NAV score (63.4 vs. 51.4).

Jul 29, 2024 | bmccancer.biomedcentral.com | Institut Gustave Roussy |Aix-Marseille Univ |Institut Paoli-Calmettes |Institut Català d’Oncologia

Alejandro Pérez-Fidalgo and Ana Oaknin contributed equally to this work.

Jul 21, 2024 | bmccancer.biomedcentral.com | Institut Gustave Roussy |Aix-Marseille Univ |Institut Paoli-Calmettes |Institut Català d’Oncologia

ENDOLUNG was an open-label phase 1/2 study of the combination of ABTL0812 plus CP in advanced or recurrent EC patients (the phase 1 also included patients with sq-NSCLC). Patients were recruited in 9 academic institutions, located in Spain and France, from November 2016 to February 2020. This study was registered with EudraCT number 2016-001352-21 and at ClinicalTrials.gov with identifier NCT03366480. During the phase 1, patients were recruited only in 6 academic institutions from Spain.

Jun 25, 2024 | academic.oup.com | Université PSL |Institut Paoli-Calmettes

The eukaryotic genome is folded in 3D within a compartmentalized nucleus. Nuclear organization constitutes a critical layer of regulation of DNA-associated transactions and an important determinant of genome integrity (1). The stability of the genome is jeopardized during DNA replication; the progression of the replisome being recurrently threatened by a broad spectrum of obstacles that cause replication fork slowing, temporary fork stalling or terminal fork collapse (2).

Jul 3, 2023 | academic.oup.com | Aix-Marseille Univ |Institut Paoli-Calmettes |Paris Sorbonne Cité |Hôpital Saint-Louis

Interstrand crosslinks (ICLs) represent a class of highly toxic lesions that covalently link the two DNA strands, thereby blocking cellular processes such as transcription or replication. As ICLs are particularly toxic to proliferating cells, ICL-inducing agents have been used in the clinic for decades, especially for cancer therapy (1).