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Oct 8, 2024 | 
thetransmitter.org | Brendan Borrell |Ellie Kincaid |Joshua R. Sanes |Charles Choi
A psychiatry researcher who received a warning letter from the U.S. Food and Drug Administration earlier this year committed research misconduct, another federal watchdog found.
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Aug 6, 2024 | 
thetransmitter.org | Jill Adams |Chloe Williams |Steve Ramirez |Joshua R. Sanes
Here is a roundup of autism-related news and research spotted around the web for the week of 5 August. Contributing writer Share this article: Tags: Spectrum, Autism, Science and society, Spotted Recessive, rare, inherited variants in noncoding regions of the genome contribute to autism. Spectrum covered previous work from the same laboratory in 2016.
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Aug 6, 2024 | 
thetransmitter.org | Steve Ramirez |Joshua R. Sanes |Jill Adams |Brady Huggett
Answers have been edited for length and clarity. What paper changed your life?: Selective erasure of a fear memory. Han J.H., Kushner S.A., Yiu A.P., Hsiang H.L., Buch T., Waisman A., Bontempi B., Neve R.L., Frankland P.W., Josselyn S.A. Science (2009)Sheena Josselyn [a contributing editor for The Transmitter] and her colleagues described how they could erase fear memories in mice by ablating a small subpopulation of cells in the amygdala.
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Aug 5, 2024 | 
thetransmitter.org | Joshua R. Sanes |Brendan Borrell |Brady Huggett |Chloe Williams
As all neuroscientists know, a host of ethical, legal and technical hurdles make it extraordinarily difficult to study the human brain at the cellular and molecular levels. Yet such studies are essential if we are to understand brain function and dysfunction and design novel therapies—especially given the major differences between the human brain and those of more accessible model organisms. How can we move forward?
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Apr 8, 2024 | 
thetransmitter.org | Nicole Rust |Steve Ramirez |Joshua R. Sanes |Sarah DeWeerdt
To better understand mood disorders—and to develop more effective treatments—should we target the brain, the mind, the environment or all three?
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Jan 29, 2024 | 
thetransmitter.org | Joshua R. Sanes |Evan Z. Macosko
Joshua R. Sanes Professor of Molecular and Cellular Biology, Harvard UniversityContributing editor, The Transmitter Tags: Defining cell types, Cellular neuroscience, Gene expression, Neural circuits, Transcriptomics Although the brain has been an object of fascination for centuries, neurobiology as we know it originated with Santiago Ramon y Cajal’s magnificent descriptions and drawings of neurons in the late 1800s.
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Jan 9, 2024 | 
nature.com | Andrew Hamel |Wenjun Yan |Xinyi Jiang |Qingnan Liang |Sreekar Mantena |Jiali Wang | +11 more
AbstractPrimary open-angle glaucoma (POAG), characterized by retinal ganglion cell death, is a leading cause of irreversible blindness worldwide. However, its molecular and cellular causes are not well understood. Elevated intraocular pressure (IOP) is a major risk factor, but many patients have normal IOP.
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Dec 18, 2023 | 
thetransmitter.org | Nicole Rust |Steve Ramirez |Joshua R. Sanes |Jill Adams
The brain may be chaotic. Does that mean our efforts to control it are doomed?
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Nov 6, 2023 | 
thetransmitter.org | Joshua R. Sanes |Alaina G. Levine |Brady Huggett |Chloe Williams
Joshua Sanes is professor of molecular and cellular biology and founding director of the Center for Brain Science at Harvard University. He and his colleagues study the formation of synapses. They have also pioneered new ways to mark and manipulate neurons and the synapses they form. For the past 20 years, Sanes and his team have focused on the retina, in which specific patterns of connections form the complex circuits that underlie the initial steps in visual perception.
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Jul 31, 2023 | 
thetransmitter.org | Brendan Borrell |Joshua R. Sanes |Angie Voyles Askham |Nicole Rust
The New York State Psychiatric Institute in New York City is undergoing an audit following a suicide that occurred during one of its clinical trials, and it has announced a change in leadership. Autism researcher Jeremy Veenstra-VanderWeele has abruptly taken the helm as the interim executive director of the institute and chair of the Columbia University psychiatry department, replacing previous interim head Helen Blair Simpson, Spectrum has learned.
