Kai Jiang

Oct 18, 2024 | mdpi.com | Tao Zhang |Yiming Wu |Xian Liu |Kai Jiang

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Feb 29, 2024 | nature.com | Dipti Rai |Victor Yin |Yixin Xu |Eugene A. Katrukha |Maarten A.F. Altelaar |Kai Jiang | +1 more

Abstractγ-Tubulin ring complex (γ-TuRC) is the major microtubule-nucleating factor. After nucleation, microtubules can be released from γ-TuRC and stabilized by other proteins, such as CAMSAPs, but the biochemical cross-talk between minus-end regulation pathways is poorly understood. Here we reconstituted this process in vitro using purified components. We found that all CAMSAPs could bind to the minus ends of γ-TuRC-attached microtubules.

Dec 21, 2023 | pubs.rsc.org | Ting Wang |Kai Jiang |Yifan Wang |Limei Xu

Prolonged near-infrared fluorescence imaging of microRNAs and proteases in vivo by aggregation-enhanced emission from DNA-AuNCs Nanomachines Developing a comprehensive strategy for imaging of various biomarkers (i.e., microRNAs and proteases) in vivo is an exceptionally formidable task. Herein, we have designed a deoxyribonucleic acids-gold nanocluster (DNA-AuNCs) nanomachine for detecting tumor-related TK1 mRNA and cathepsin B in living cells and in vivo.

Dec 15, 2023 | onlinelibrary.wiley.com | Qi Fan |Kai Jiang |Bo Liu |Huanfeng Jiang

1 Introduction Dearomatization reactions provide fundamental methods for converting abundant planar aromatics into elaborated 3D molecules.[1-6] After receiving considerable attention in the synthetic community, Pd(0) and π-allyl Pd(II) have clearly defined mechanisms.[7-11] The current pathways for Pd-catalyzed dearomatization of (hetero)arenes are mostly two-electron processes, requiring harsh reaction conditions, such as high temperature, to overcome the energy barrier of the dearomative...

Sep 25, 2023 | cell.com | Kai Jiang

Highlights•A novel subset of cardiac macrophages, termed Bhlhe41+ Mφs, ameliorates ischemic injury•Microenvironment post MI specifically activates Bhlhe41+ Mφs in the developing infarct zone•The Bhlhe41+ Mφs reduce myofibroblast activity and thus prevent excessive fibrosisSummaryThe immune system plays a critical role during myocardial injury, contributing to repair and remodeling post myocardial infarction (MI).