Lin-Bo Wang

Jul 9, 2024 | nature.com | Yu Guo |Jia You |Lin-Bo Wang |Yue-Ting Deng |Qiang Dong |Jian-Feng Feng | +1 more

AbstractRecent expansion of proteomic coverage opens unparalleled avenues to unveil new biomarkers of Alzheimer’s disease (AD). Among 6,361 cerebrospinal fluid (CSF) proteins analysed from the ADNI database, YWHAG performed best in diagnosing both biologically (AUC = 0.969) and clinically (AUC = 0.857) defined AD. Four- (YWHAG, SMOC1, PIGR and TMOD2) and five- (ACHE, YWHAG, PCSK1, MMP10 and IRF1) protein panels greatly improved the accuracy to 0.987 and 0.975, respectively.

Nov 27, 2023 | nature.com | Jia You |Ju-Jiao Kang |Jian-Feng Feng |Wei Cheng |Lin-Bo Wang

AbstractDeveloping a single-domain assay to identify individuals at high risk of future events is a priority for multi-disease and mortality prevention. By training a neural network, we developed a disease/mortality-specific proteomic risk score (ProRS) based on 1461 Olink plasma proteins measured in 52,006 UK Biobank participants.