Yue-Ting Deng

Aug 29, 2024 | nature.com | Ju-Jiao Kang |Yue-Ting Deng |Qiang Dong |Jian-Feng Feng |Wei Cheng

AbstractEducational attainment (EA), socioeconomic status (SES) and cognition are phenotypically and genetically linked to health outcomes. However, the role of copy number variations (CNVs) in influencing EA/SES/cognition remains unclear.

Jul 15, 2024 | nature.com | Yue-Ting Deng |Jujiao Kang |Ying Zhu |Qiang Dong |Jianfeng Feng |Wei Cheng

AbstractThe genetic contribution of protein-coding variants to immune-mediated diseases (IMDs) remains underexplored. Through whole exome sequencing of 40 IMDs in 350,770 UK Biobank participants, we identified 162 unique genes in 35 IMDs, among which 124 were novel genes. Several genes, including FLG which is associated with atopic dermatitis and asthma, showed converging evidence from both rare and common variants.

Jul 9, 2024 | nature.com | Yu Guo |Jia You |Lin-Bo Wang |Yue-Ting Deng |Qiang Dong |Jian-Feng Feng | +1 more

AbstractRecent expansion of proteomic coverage opens unparalleled avenues to unveil new biomarkers of Alzheimer’s disease (AD). Among 6,361 cerebrospinal fluid (CSF) proteins analysed from the ADNI database, YWHAG performed best in diagnosing both biologically (AUC = 0.969) and clinically (AUC = 0.857) defined AD. Four- (YWHAG, SMOC1, PIGR and TMOD2) and five- (ACHE, YWHAG, PCSK1, MMP10 and IRF1) protein panels greatly improved the accuracy to 0.987 and 0.975, respectively.