Ju-Jiao Kang

Aug 29, 2024 | nature.com | Ju-Jiao Kang |Yue-Ting Deng |Qiang Dong |Jian-Feng Feng |Wei Cheng

AbstractEducational attainment (EA), socioeconomic status (SES) and cognition are phenotypically and genetically linked to health outcomes. However, the role of copy number variations (CNVs) in influencing EA/SES/cognition remains unclear.

Nov 27, 2023 | nature.com | Jia You |Ju-Jiao Kang |Jian-Feng Feng |Wei Cheng |Lin-Bo Wang

AbstractDeveloping a single-domain assay to identify individuals at high risk of future events is a priority for multi-disease and mortality prevention. By training a neural network, we developed a disease/mortality-specific proteomic risk score (ProRS) based on 1461 Olink plasma proteins measured in 52,006 UK Biobank participants.

Oct 19, 2023 | nature.com | Tobias Banaschewski |Gareth Barker |Sylvane Desrivières |Herta Flor |Penny Gowland |Andreas Heinz | +17 more

AbstractThe cerebral ventricles are recognized as windows into brain development and disease, yet their genetic architectures, underlying neural mechanisms and utility in maintaining brain health remain elusive. Here we aggregated genetic and neuroimaging data from 61,974 participants (age range, 9 to 98 years) in five cohorts to elucidate the genetic basis of ventricular morphology and examined their overlap with neuropsychiatric traits.