Jia You

Jan 8, 2025 | fis.tu-dresden.de | Shi Chen |IMAGEN Consortium |Jia You |Wei Zhang

Abstract Externe IDs Scopus 85181497496 SchlagworteHumans, Genome-Wide Association Study, Hypothalamus/metabolism, Male, Female, Adult, Mental Disorders/genetics, ADAMTS Proteins/genetics, Middle Aged, Mendelian Randomization Analysis

Aug 6, 2024 | nature.com | Jia You |Wei Cheng |Xiaojun Xu |Minming Zhang |Linbo Wang

AbstractParkinson’s disease (PD) exhibits heterogeneity in terms of symptoms and prognosis, likely due to diverse neuroanatomical alterations. This study employs a contrastive deep learning approach to analyze Magnetic Resonance Imaging (MRI) data from 932 PD patients and 366 controls, aiming to disentangle PD-specific neuroanatomical alterations.

Jul 9, 2024 | nature.com | Yu Guo |Jia You |Lin-Bo Wang |Yue-Ting Deng |Qiang Dong |Jian-Feng Feng | +1 more

AbstractRecent expansion of proteomic coverage opens unparalleled avenues to unveil new biomarkers of Alzheimer’s disease (AD). Among 6,361 cerebrospinal fluid (CSF) proteins analysed from the ADNI database, YWHAG performed best in diagnosing both biologically (AUC = 0.969) and clinically (AUC = 0.857) defined AD. Four- (YWHAG, SMOC1, PIGR and TMOD2) and five- (ACHE, YWHAG, PCSK1, MMP10 and IRF1) protein panels greatly improved the accuracy to 0.987 and 0.975, respectively.

Mar 19, 2024 | mdpi.com | Zhao Wang |Jia You |Xiaoyue Xu |Ying Yang

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Feb 11, 2024 | nature.com | Jia You |Qiang Dong |Jian-Feng Feng |Wei Cheng

AbstractThe advent of proteomics offers an unprecedented opportunity to predict dementia onset. We examined this in data from 52,645 adults without dementia in the UK Biobank, with 1,417 incident cases and a follow-up time of 14.1 years. Of 1,463 plasma proteins, GFAP, NEFL, GDF15 and LTBP2 consistently associated most with incident all-cause dementia (ACD), Alzheimer’s disease (AD) and vascular dementia (VaD), and ranked high in protein importance ordering.