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Nov 18, 2024 | 
nature.com | Yu Guo |Linbo Wang |Jujiao Kang |Qiang Dong |Jianfeng Feng |Wei Cheng
AbstractPathophysiological evolutions in early-stage Alzheimer’s disease (AD) are not well understood. We used data of 2923 Olink plasma proteins from 51,296 non-demented middle-aged adults. During a follow-up of 15 years, 689 incident AD cases occurred. Cox-proportional hazard models were applied to identify AD-associated proteins in different time intervals. Through linking to protein categories, changing sequences of protein z-scores can reflect pathophysiological evolutions.
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Nov 1, 2024 | 
pubs.rsc.org | Wei Cheng |Nanjing Normal |Bo Zhang
An enzyme-responsive double-locked amonafide prodrug for the treatment of glioblastoma with minimal side effects†
Amonafide (ANF), a topoisomerase II inhibitor and DNA intercalator, has exhibited promise in phase II trials but faces significant limitations due to adverse side effects.
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Aug 29, 2024 | 
nature.com | Ju-Jiao Kang |Yue-Ting Deng |Qiang Dong |Jian-Feng Feng |Wei Cheng
AbstractEducational attainment (EA), socioeconomic status (SES) and cognition are phenotypically and genetically linked to health outcomes. However, the role of copy number variations (CNVs) in influencing EA/SES/cognition remains unclear.
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Aug 6, 2024 | 
nature.com | Jia You |Wei Cheng |Xiaojun Xu |Minming Zhang |Linbo Wang
AbstractParkinson’s disease (PD) exhibits heterogeneity in terms of symptoms and prognosis, likely due to diverse neuroanatomical alterations. This study employs a contrastive deep learning approach to analyze Magnetic Resonance Imaging (MRI) data from 932 PD patients and 366 controls, aiming to disentangle PD-specific neuroanatomical alterations.
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Jul 15, 2024 | 
nature.com | Yue-Ting Deng |Jujiao Kang |Ying Zhu |Qiang Dong |Jianfeng Feng |Wei Cheng
AbstractThe genetic contribution of protein-coding variants to immune-mediated diseases (IMDs) remains underexplored. Through whole exome sequencing of 40 IMDs in 350,770 UK Biobank participants, we identified 162 unique genes in 35 IMDs, among which 124 were novel genes. Several genes, including FLG which is associated with atopic dermatitis and asthma, showed converging evidence from both rare and common variants.
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Jul 9, 2024 | 
nature.com | Yu Guo |Jia You |Lin-Bo Wang |Yue-Ting Deng |Qiang Dong |Jian-Feng Feng | +1 more
AbstractRecent expansion of proteomic coverage opens unparalleled avenues to unveil new biomarkers of Alzheimer’s disease (AD). Among 6,361 cerebrospinal fluid (CSF) proteins analysed from the ADNI database, YWHAG performed best in diagnosing both biologically (AUC = 0.969) and clinically (AUC = 0.857) defined AD. Four- (YWHAG, SMOC1, PIGR and TMOD2) and five- (ACHE, YWHAG, PCSK1, MMP10 and IRF1) protein panels greatly improved the accuracy to 0.987 and 0.975, respectively.
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Mar 15, 2024 | 
onlinelibrary.wiley.com | Di Chen |Tianye Jia |Wei Cheng |Sylvane Desrivières
1 INTRODUCTION Understanding the complex relationship between neuroimaging and human behaviors is a fundamental goal of neuroscience. For this purpose, functional and structural MRI (fMRI and sMRI) as non-invasive neuroimaging techniques with excellent spatial resolution have been widely used to investigate potential neural risk factors (Bulik-Sullivan, Loh, et al., 2015; Ing et al., 2019; Jia et al., 2020).
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Feb 11, 2024 | 
nature.com | Jia You |Qiang Dong |Jian-Feng Feng |Wei Cheng
AbstractThe advent of proteomics offers an unprecedented opportunity to predict dementia onset. We examined this in data from 52,645 adults without dementia in the UK Biobank, with 1,417 incident cases and a follow-up time of 14.1 years. Of 1,463 plasma proteins, GFAP, NEFL, GDF15 and LTBP2 consistently associated most with incident all-cause dementia (ACD), Alzheimer’s disease (AD) and vascular dementia (VaD), and ranked high in protein importance ordering.
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Jan 16, 2024 | 
nature.com | Jian-Feng Feng |Wei Cheng
AbstractInconsistent findings exist regarding the potential association between polluted air and Parkinson’s disease (PD), with unclear insights into the role of inherited sensitivity. This study sought to explore the potential link between various air pollutants and PD risk, investigating whether genetic susceptibility modulates these associations. The population-based study involved 312,009 initially PD-free participants with complete genotyping data.
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Jan 11, 2024 | 
nature.com | Bei Zhang |Edmund T. Rolls |Xiang Wang |Wei Cheng
AbstractWe describe evidence for dissociable roles of the medial and lateral orbitofrontal cortex (OFC) in major depressive disorder (MDD) from structure, functional activation, functional connectivity, metabolism, and neurochemical systems.
