Qiang Dong

Nov 18, 2024 | nature.com | Yu Guo |Linbo Wang |Jujiao Kang |Qiang Dong |Jianfeng Feng |Wei Cheng

AbstractPathophysiological evolutions in early-stage Alzheimer’s disease (AD) are not well understood. We used data of 2923 Olink plasma proteins from 51,296 non-demented middle-aged adults. During a follow-up of 15 years, 689 incident AD cases occurred. Cox-proportional hazard models were applied to identify AD-associated proteins in different time intervals. Through linking to protein categories, changing sequences of protein z-scores can reflect pathophysiological evolutions.

Aug 29, 2024 | nature.com | Ju-Jiao Kang |Yue-Ting Deng |Qiang Dong |Jian-Feng Feng |Wei Cheng

AbstractEducational attainment (EA), socioeconomic status (SES) and cognition are phenotypically and genetically linked to health outcomes. However, the role of copy number variations (CNVs) in influencing EA/SES/cognition remains unclear.

Jul 15, 2024 | nature.com | Yue-Ting Deng |Jujiao Kang |Ying Zhu |Qiang Dong |Jianfeng Feng |Wei Cheng

AbstractThe genetic contribution of protein-coding variants to immune-mediated diseases (IMDs) remains underexplored. Through whole exome sequencing of 40 IMDs in 350,770 UK Biobank participants, we identified 162 unique genes in 35 IMDs, among which 124 were novel genes. Several genes, including FLG which is associated with atopic dermatitis and asthma, showed converging evidence from both rare and common variants.

Jul 9, 2024 | nature.com | Yu Guo |Jia You |Lin-Bo Wang |Yue-Ting Deng |Qiang Dong |Jian-Feng Feng | +1 more

AbstractRecent expansion of proteomic coverage opens unparalleled avenues to unveil new biomarkers of Alzheimer’s disease (AD). Among 6,361 cerebrospinal fluid (CSF) proteins analysed from the ADNI database, YWHAG performed best in diagnosing both biologically (AUC = 0.969) and clinically (AUC = 0.857) defined AD. Four- (YWHAG, SMOC1, PIGR and TMOD2) and five- (ACHE, YWHAG, PCSK1, MMP10 and IRF1) protein panels greatly improved the accuracy to 0.987 and 0.975, respectively.

Apr 19, 2024 | onlinelibrary.wiley.com | Qiang Dong |Kowloon Tong |Tuoya Naren |Lei Zhang

Introduction Covalent organic polymers/frameworks (COPs/COFs) with single-crystal X-ray diffraction (SCXRD) analysis have attracted tremendous attention since the precise structural information provides lots of accurate information including atomic position and interaction, stacking mode, structure-function relationship, etc.1 These factors not only help us to understand the kinetics and thermodynamics of single crystal growth of COPs, but also provides us the possible strategies to finely...