Linghua Wang

3 weeks ago | cell.com | Zilong Zhao |Benxia Hu |Yalan Deng |Melinda Soeung |Jun Yao |Lanxin Bei | +25 more

Keywords sickle cell disease renal medullary carcinoma ferroptosis genomic architecture alteration Hi-C H2S SLC7A11 SMARCB1 immune checkpoint inhibitors CD8+ T cells Introduction Sickle cell disease (SCD), the most prevalent inherited blood disorder,1 arises from the homozygous HbS mutation (GAG>GTG: βGlu6Val), causing hemoglobin abnormalities that make red blood cells (RBCs) assume a sickle or crescent shape.2 Individuals with SCD have RBCs prone to hemolysis, leading to vaso-occlusive...

3 weeks ago | cell.com | Zilong Zhao |Benxia Hu |Yalan Deng |Melinda Soeung |Jun Yao |Lanxin Bei | +25 more

Keywords sickle cell disease renal medullary carcinoma ferroptosis genomic architecture alteration Hi-C H2S SLC7A11 SMARCB1 immune checkpoint inhibitors CD8+ T cells Introduction Sickle cell disease (SCD), the most prevalent inherited blood disorder,1 arises from the homozygous HbS mutation (GAG>GTG: βGlu6Val), causing hemoglobin abnormalities that make red blood cells (RBCs) assume a sickle or crescent shape.2 Individuals with SCD have RBCs prone to hemolysis, leading to vaso-occlusive...

Jan 24, 2025 | nature.com | Kyle Coleman |Jeong Hwan Park |Hanying Yan |Isabel Barnfather |Joshua D. Rabinowitz |Yanxiang Deng | +5 more

Correction to: Nature Methods https://doi.org/10.1038/s41592-024-02574-2, published online 15 January 2025. In the version of the article initially published, the Data availability and Code availability sections were inadvertently omitted. These sections have now been included in the HTML and PDF versions of the article. About this articleColeman, K., Schroeder, A., Loth, M. et al. Author Correction: Resolving tissue complexity by multimodal spatial omics modeling with MISO. Nat Methods (2025).

Jan 15, 2025 | nature.com | Kyle Coleman |Jeong Hwan Park |Hanying Yan |Joshua D. Rabinowitz |Yanxiang Deng |Edward Lee | +5 more

AbstractSpatial molecular profiling has provided biomedical researchers valuable opportunities to better understand the relationship between cellular localization and tissue function. Effectively modeling multimodal spatial omics data is crucial for understanding tissue complexity and underlying biology.

Jan 9, 2025 | nature.com | Pavlos Msaouel |Rahul Sheth |Amishi Y. Shah |Amado J. Zurita |Giannicola Genovese |Minghao Dang | +3 more

AbstractWe conducted a phase I trial to determine the optimal dose of triplet therapy with the tyrosine kinase inhibitor sitravatinib plus nivolumab plus ipilimumab in 22 previously untreated patients with advanced clear cell renal cell carcinoma. The primary endpoint was safety.