Liuliu Yang

Aug 6, 2024 | biorxiv.org | Liuliu Yang |Tuo Zhang |Xue Dong |Jian Ge

AbstractThere is a paucity of human models to study immune-mediated host damage. Here, we utilized the GeoMx spatial multi-omics platform to analyze immune cell changes in COVID-19 pancreatic autopsy samples, revealing an accumulation of proinflammatory macrophages. Single cell RNA-seq analysis of human islets exposed to SARS-CoV-2 or Coxsackievirus B4 (CVB4) viruses identified activation of proinflammatory macrophages and β cell pyroptosis.

Mar 27, 2024 | chemistry-europe.onlinelibrary.wiley.com | Si Ma |Yuxin Hou |Liuliu Yang |Huijuan Yue

Conflict of interests The authors declare no conflict of interest. Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.

Jan 17, 2024 | cell.com | Liuliu Yang |Manoj Nair |Oliver Harschnitz |Human Technopole

Highlights•hPSC-derived DA neurons are susceptible to SARS-CoV-2 infection•SARS-CoV-2 infection of DA neurons triggers cellular senescence response•Several FDA-approved drugs were identified to rescue senescence of DA neurons•Cellular senescence was found in substantia nigra tissues of COVID-19 patientsSummaryCOVID-19 patients commonly present with signs of central nervous system and/or peripheral nervous system dysfunction.

Jan 17, 2024 | cell.com | Liuliu Yang |Manoj Nair |Oliver Harschnitz |Jiajun Zhu |Pengfei Wang |So Yeon Koo | +17 more

hPSC differentiation toward DA neuronsMidbrain dopaminergic neuron differentiation were performed using H9, MEL1 and SNCA different copy numbers hPSCs, which include NURR1: GFP hPSC. hPSCs were grown on VTN-N (Thermo Fisher Scientific)-coated 6-well plates in E8-essential medium. Cells were maintained at 37°C, 5% CO2.