Tuo Zhang

Sep 11, 2024 | mdpi.com | Mingzan Zhang |Tuo Zhang |Yuan Wang |Xueyi Duan

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Aug 6, 2024 | biorxiv.org | Liuliu Yang |Tuo Zhang |Xue Dong |Jian Ge

AbstractThere is a paucity of human models to study immune-mediated host damage. Here, we utilized the GeoMx spatial multi-omics platform to analyze immune cell changes in COVID-19 pancreatic autopsy samples, revealing an accumulation of proinflammatory macrophages. Single cell RNA-seq analysis of human islets exposed to SARS-CoV-2 or Coxsackievirus B4 (CVB4) viruses identified activation of proinflammatory macrophages and β cell pyroptosis.

Jan 17, 2024 | cell.com | Liuliu Yang |Manoj Nair |Oliver Harschnitz |Jiajun Zhu |Pengfei Wang |So Yeon Koo | +17 more

hPSC differentiation toward DA neuronsMidbrain dopaminergic neuron differentiation were performed using H9, MEL1 and SNCA different copy numbers hPSCs, which include NURR1: GFP hPSC. hPSCs were grown on VTN-N (Thermo Fisher Scientific)-coated 6-well plates in E8-essential medium. Cells were maintained at 37°C, 5% CO2.

Dec 17, 2023 | biorxiv.org | Tuo Zhang |Ryan J. Marina |Rab K Prinjha |Karen Adelman

AbstractExposure of unicellular or multicellular organisms to adverse environmental conditions, including nutrient deprivation, may induce a state of suspended animation or diapause. The diapause minimizes the organism's reliance on external energy sources and ensures survival. Among different forms of diapause, embryonic diapause, caused by a limited supply of nutrients to the growing embryos, is particularly challenging for the organism.

Nov 8, 2023 | nature.com | Tuo Zhang |Chengyang Liu

AbstractAfter the discovery of insulin, a century ago, extensive work has been done to unravel the molecular network regulating insulin secretion. Here we performed a chemical screen and identified AZD7762, a compound that potentiates glucose-stimulated insulin secretion (GSIS) of a human β cell line, healthy and type 2 diabetic (T2D) human islets and primary cynomolgus macaque islets.