Minh-Duy Phan

Oct 24, 2024 | journals.plos.org | Brian Forde |Molecular Biosciences |Minh-Duy Phan |Leah Roberts

Loading metrics Open Access Peer-reviewedResearch Article ? This is an uncorrected proof. Citation: Nhu NTK, Forde BM, Ben Zakour NL, Phan M-D, Roberts LW, Beatson SA, et al. (2024) Evolution of the pheV-tRNA integrated genomic island in Escherichia coli. PLoS Genet 20(10): e1011459. https://doi.org/10.1371/journal.pgen.1011459Editor: Diarmaid Hughes, Uppsala University, SWEDENReceived: May 12, 2024; Accepted: October 14, 2024; Published: October 24, 2024Copyright: © 2024 Nhu et al.

Oct 18, 2024 | microbiologyresearch.org | Timothy J. Kidd |Amy Dumigan |Brian Forde |Minh-Duy Phan

Background Klebsiella pneumoniae (Kpn) is an important respiratory pathogen associated with significant mortality fierce inflammatory responses and high rates of antimicrobial resistance. The increasing incidence of multidrug resistant Kpn has significantly narrowed the therapeutic options available; as such there is an urgent need to better understand Kpn pathophysiology to identify novel therapeutic targets.

Oct 17, 2024 | nature.com | Fabrice E Graf |Richard Goodman |Esther Picton-Barlow |Minh-Duy Phan |Mark Schembri |Adam Roberts | +2 more

AbstractInfections with Enterobacterales (E) are increasingly difficult to treat due to antimicrobial resistance. After ceftriaxone replaced chloramphenicol (CHL) as empiric therapy for suspected sepsis in Malawi in 2004, extended-spectrum beta-lactamase (ESBL)-E rapidly emerged. Concurrently, resistance to CHL in Escherichia coli and Klebsiella spp. decreased, raising the possibility of CHL re-introduction.

Apr 16, 2024 | elifesciences.org | Minh-Duy Phan |Steven Hancock |Kate Peters |Laura Álvarez-Fraga

eLife assessment This valuable study presents findings characterising the genomic features of E. coli isolated from neonatal meningitis from seven countries, and documents bacterial persistence and reinfection in two case studies. The genomic analyses are solid, although the inclusion of a larger number of isolates from more diverse geographies would have strengthened the generalisability of findings.

Feb 20, 2024 | nature.com | Seung Jae Kim |Minh-Duy Phan |Matthew Sullivan |Katharine M. Irvine |Scott A. Beatson |Matthew Sweet | +4 more

AbstractBacteria adapt to selective pressure in their immediate environment in multiple ways. One mechanism involves the acquisition of independent mutations that disable or modify a key pathway, providing a signature of adaptation via convergent evolution. Extra-intestinal pathogenic Escherichia coli (ExPEC) belonging to sequence type 95 (ST95) represent a global clone frequently associated with severe human infections including acute pyelonephritis, sepsis, and neonatal meningitis.