Yanan Li

Dec 10, 2024 | nature.com | Kejia Li |Shijie Chen |Keyun Wang |Yan Wang |Yuying Ye |Zheng Fang | +14 more

By using a limited-proteolysis strategy that employs a large amount of trypsin to generate peptides directly from native proteins, we found that ligand-induced protein local stability shifts can be sensitively detected on a proteome-wide scale. This enabled us to develop the peptide-centric local stability assay, a modification-free approach that achieves unprecedented sensitivity in proteome-wide target identification and binding-region determination. We demonstrate the broad applications of the peptide-centric local stability assay by investigating interactions across various biological contexts. The peptide-centric local stability assay (PELSA) can be used to determine ligand-binding targets and binding regions on a proteome-wide scale with high sensitivity.

Nov 14, 2024 | pericles.pericles-prod.literatumonline.com | Yanan Li |Xi'an Jiaotong |P.R. China |Yuanjun Zhao

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Nov 14, 2024 | pubs.rsc.org | Yanan Li |Zhilong Xu |Lei Fan

Folic-acid-functionalized Fe3O4@C@Pt nanozyme for synergistic catalytic-photothermal tumor therapy† Nanozymes are enzyme-like nanomaterials that have attracted considerable interest because of their high stability, ease of preparation, and tunable catalytic performance, particularly in cancer treatment. However, ineffective accumulation of nanozymes at tumor sites results in low catalytic therapeutic efficiency and even affects synergistic therapy.

Nov 10, 2024 | respiratory-research.biomedcentral.com | Ye Yin |Guofeng Zhang |Wei Li |Xiaofeng Xiong |Yanan Li |Yin He | +1 more

A multicenter 1:1 matched case-control study was adopted. Three tertiary teaching hospitals, including Tongji Hospital affiliated to Huazhong University of science and technology, the First affiliated Hospital of Zhengzhou University, and the First Affiliated Hospital of Guangxi medical University, participated in this study. Cases of ILS in patients younger than 14 years treated with ICG from January 2023 to December 2023 in the three hospitals were collected.

Oct 8, 2024 | mdpi.com | Qin Zhang |Yanan Li |Sha Geng |Qian Liu

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