Robert Clarke

2 months ago | nature.com | Neil Wright |Hannah Fry |Yiping Chen |Huaidong Du |Canqing Yu |Dianjianyi Sun | +6 more

AbstractProteomics offers unique insights into human biology and drug development, but few studies have directly compared the utility of different proteomics platforms. We measured plasma levels of 2168 proteins in 3976 Chinese adults using both Olink Explore and SomaScan platforms. The correlation of protein levels between platforms was modest (median rho = 0.29), with protein abundance and data quality parameters being key factors influencing correlation.

Aug 8, 2024 | nature.com | M. Austin Argentieri |Derrick Bennett |Ashwag Albukhari |Jun Lv |Iona Y. Millwood |Hannah Fry | +6 more

AbstractCirculating plasma proteins play key roles in human health and can potentially be used to measure biological age, allowing risk prediction for age-related diseases, multimorbidity and mortality. Here we developed a proteomic age clock in the UK Biobank (n = 45,441) using a proteomic platform comprising 2,897 plasma proteins and explored its utility to predict major disease morbidity and mortality in diverse populations.

Jul 23, 2024 | nature.com | Wei Gan |Robert Clarke |Masaru Koido |Masahiro Kanai |Yukinori Okada |Yoichiro Kamatani | +7 more

AbstractElevated blood pressure (BP) is major risk factor for cardiovascular diseases (CVD). Genome-wide association studies (GWAS) conducted predominantly in populations of European ancestry have identified >2,000 BP-associated loci, but other ancestries have been less well-studied. We conducted GWAS of systolic, diastolic, pulse, and mean arterial BP in 100,453 Chinese adults. We identified 128 non-overlapping loci associated with one or more BP traits, including 74 newly-reported associations.

Jun 8, 2023 | nature.com | Pek Kei Im |Neil Wright |Yiping Chen |Huaidong Du |Canqing Yu |Robert Clarke | +3 more

Study populationDetails of the CKB study design and methods have been previously reported55. Briefly, 512,724 adults aged 30–79 years were recruited from ten geographically diverse (five rural and five urban) areas across China during 2004–2008.