Thomas D. Als

Jun 16, 2024 | nature.com | Jacob Bergstedt |Ziyan Ma |Shuyang Yao |Nadine Staples Parker |Oleksandr Frei |Joeri J. Meijsen | +12 more

AbstractMajor depressive disorder (MDD) and cardiovascular disease (CVD) are often comorbid, resulting in excess morbidity and mortality. Here we show that CVDs share most of their genetic risk factors with MDD. Multivariate genome-wide association analysis of shared genetic liability between MDD and atherosclerotic CVD revealed seven loci and distinct patterns of tissue and brain cell-type enrichments, suggesting the involvement of the thalamus.

Jul 18, 2023 | nature.com | Thomas D. Als |Jakob Grove |Georgios Voloudakis |Karen Therrien |Joonas Naamanka |Daniel F Levey | +15 more

AbstractDepression is a common psychiatric disorder and a leading cause of disability worldwide. Here we conducted a genome-wide association study meta-analysis of six datasets, including >1.3 million individuals (371,184 with depression) and identified 243 risk loci. Overall, 64 loci were new, including genes encoding glutamate and GABA receptors, which are targets for antidepressant drugs.

Mar 1, 2023 | nature.com | Ditte Demontis |G. Bragi Walters |Georgios Athanasiadis |Raymond K Walters |Karen Therrien |Georgios Voloudakis | +26 more

Correction to: Nature Genetics https://doi.org/10.1038/s41588-022-01285-8. Published online 26 January 2023. In the version of this article originally published, the first name of Jonna Kuntsi, of the ADHD Working Group of the Psychiatric Genomics Consortium, was misspelled as Joanna. In addition, the Acknowledgements omitted to thank the employees and research participants of 23andMe for making this work possible. The errors have been corrected in the HTML and PDF versions of the article.