Xiaopeng Li

Nov 5, 2024 | onlinelibrary.wiley.com | Ying Cao |Lei Sun |Xiaopeng Li |Qi Zhang

1 Introduction The palatine tonsil is an important immune-active tissue [1] and the first barrier to foreign bacteria entering the body. Inflammatory changes and hypertrophy in the palatine tonsils are common pediatric diseases. Inflammatory diseases have a sudden onset and progress rapidly, potentially to peritonsil cellulitis and abscess, which may be life-threatening [2].

Oct 21, 2024 | amazon.science | Nan Jiang |Xiaopeng Li |Shiqi Wang |Qiang Zhou

In the domain of code generation, self-debugging is crucial. It allows LLMs to refine their generated code based on execution feedback. This is particularly important because generating correct solutions in one attempt proves challenging for complex tasks.

Sep 25, 2024 | mdpi.com | Ying Xu |Yi Zou |Lei Liu |Xiaopeng Li

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Jul 21, 2024 | arxiv.org | Xiaopeng Li

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Jun 25, 2024 | nature.com | Haifeng Jiao |Xiaopeng Li |Ying Li |Yuting Guo |Xiaoyu Hu |Yiqun Luo | +6 more

Migrasomes, enriched with signaling molecules such as chemokines, cytokines and angiogenic factors, play a pivotal role in the spatially defined delivery of these molecules, influencing critical physiological processes including organ morphogenesis and angiogenesis. The mechanism governing the accumulation of signaling molecules in migrasomes has been elusive. In this study, we show that secretory proteins, including signaling proteins, are transported into migrasomes by secretory carriers via both the constitutive and regulated secretion pathways. During cell migration, a substantial portion of these carriers is redirected to the rear of the cell and actively transported into migrasomes, driven by the actin-dependent motor protein Myosin-5a. Once at the migrasomes, these carriers fuse with the migrasome membrane through SNARE-mediated mechanisms. Inhibiting migrasome formation significantly reduces secretion, suggesting migrasomes as a principal secretion route in migrating cells. Our findings reveal a specialized, highly localized secretion paradigm in migrating cells, conceptually paralleling the targeted neurotransmitter release observed in neuronal systems.