Yi Xue

Jan 10, 2025 | nature.com | Chang Li |Yi Xue |Jun Yao |Shan Sun |Mengyi Yang |Sen-fang Sui | +5 more

SNARE (soluble N-ethylmaleimide sensitive factor attachment protein receptor) proteins are the minimal machinery required for vesicle fusion in eukaryotes. Formation of a highly stable four-helix bundle consisting of SNARE motif of these proteins, drives vesicle/membrane fusion involved in several physiological processes such as neurotransmission. Recycling/disassembly of the protein machinery involved in membrane fusion is essential and is facilitated by an AAA+ ATPase, N-ethylmaleimide sensitive factor (NSF) in the presence of an adapter protein, α-SNAP. Here we use single-molecule fluorescence spectroscopy approaches to elucidate the chain of events that occur during the disassembly of SNARE complex by NSF. Our observations indicate two major pathways leading to the sequential disassembly of the SNARE complex: one where a syntaxin separated intermediate state is observed before syntaxin disassembles first, and a second where Vamp disassembles from the other proteins first. These studies uncover two parallel sequential pathways for the SNARE disassembly by NSF along with a syntaxin separated intermediate that couldn’t be observed otherwise. SNARE proteins are the minimal machinery required for the vesicle fusion in eukaryotes. Here the authors use single-molecule fluorescence spectroscopy to elucidate the chain of events during the disassembly of SNARE complex by NSF, showing two parallel sequential pathways for SNARE disassembly.

May 20, 2024 | lexology.com | Yi Xue

在“大数据+大模型+大算力”的架构下，以ChatGPT为代表的人工智能大模型已经可以协助用户完成诸多复杂任务，成为人们提高工作效率的首选工具。由此衍生的有关人工智能生成物（AIGC）的可版权性问题也引发了广泛热议。本文将以近期北京互联网法院作出的AI文生图著作权侵权纠纷案判决为起点，探讨影响AI文生图可版权性的主要因素。 一、司法实践立场 北京互联网法院在2023年11月27日作出的“AI文生图著作权纠纷案”（“春风图案”）判决书中，首次在司法层面认可了AI文生图的可版权性，支持原告拥有AI文生图《春风送来了温柔》的著作权的主张。在该案中，原告通过某社交平台发布了一张由开源软件生成的AI文生图，而被告在其某内容创作平台账号发布的诗歌文章中未经原告同意使用了截去署名水印的涉案图片。因此，原告诉至法院，主张其拥有涉案AI文生图的著作权，并指称被告侵犯了其署名权及信息网络传播权。...

May 19, 2024 | loublaser.substack.com | Lou Blaser |Matthew Long |Yi Xue |Fabienne Mannherz

Audio playback is not supported on your browser. Please upgrade. My dear reader friend, If you procrastinate — as we all do from time to time — I’ll save you a step and say don’t bother trying to fix it with a new time management tool. Actually, maybe forget fixing it at all. But I’m getting ahead of myself. First, let’s look at some good news.

Apr 7, 2024 | loublaser.substack.com | Lou Blaser |Yi Xue

☕️ My dear reader friend, To get better at being grateful, I challenged myself to stop complaining for a week and promised to share my results with you. And I will, but first, can I tell you something I discovered?

Apr 5, 2024 | loublaser.substack.com | Lou Blaser |Yi Xue

is a mother, wife, daughter, and sister. She’s also been many things at different times in her career: musician, engineer, business executive, writer, and advisor. Yi writes stories about her family of origin living through different times and from faraway places, being a first-generation immigrant redefining herself, being a woman of color navigating corporate America, and finding the power to make her own decisions and living life on her own terms. Yi lives in Camas, Washington.