Broad Institute

The Broad Institute of MIT and Harvard was established in 2004 with the goal of enhancing human health. It focuses on genomics to deepen our knowledge of disease biology and treatment, paving the way for innovative therapies in the future.

National

English

Blog

Outlet metrics

Domain Authority

Ranking

Global

#100577

United States

#39817

Science and Education/Biology

#63

Traffic sources

Monthly visitors

Articles

Scientists discover network of cells and genes involved in Crohn’s disease complication

3 days ago | broadinstitute.org | Allessandra DiCorato

Up to half of patients with Crohn’s disease, an inflammatory bowel disease, develop a complication called fibrosis, where the gut becomes scarred and obstructed, causing pain and bloating. Currently, the only treatment option for these gut “strictures” is surgery.
#WhyIScienceQ&A: A neuroscientist advocates for stepping outside your comfort zone in research

1 week ago | broadinstitute.org | Allessandra DiCorato

At first, Giulia Monti thought she’d work in another neuroscience lab as a postdoctoral researcher. She had spent the last four years earning her PhD at Aarhus University in Denmark, studying proteins called cargo receptors in Alzheimer’s disease. But then she stumbled upon the lab of Anna Greka, a core institute member at the Broad Institute and a nephrologist at Mass General Brigham.
New technique expands cells to sequence DNA and capture fine structural details

4 weeks ago | broadinstitute.org | Allessandra DiCorato

Broad Institute researchers have developed a technology that provides new insight into how disruptions in the nucleus of the cell can impact health and disease. The approach, called expansion in situ genome sequencing, allows scientists to sequence DNA and map its location relative to proteins within cell nuclei. The method uses a gel to expand cells while keeping them intact, enabling both sequencing and high-resolution imaging within the same cells.
Making antibiotics more potent against drug-resistant bacteria

1 month ago | broadinstitute.org | Allessandra DiCorato

Researchers have created a pipeline for discovering unique combinations of molecules that increase the effectiveness of antibiotics against drug-resistant bacteria. The team, led by scientists at the Broad Institute and the Tufts University School of Medicine, used a microfluidic approach to screen more than 1 million combinations of antibiotics, small molecules, and bacteria.
Gene editing disrupts Huntington’s mutation in mice

1 month ago | broadinstitute.org | Allessandra DiCorato

Broad Institute researchers have developed a way to edit the genetic sequences at the root of Huntington’s disease and Friedreich’s ataxia. The conditions are two of more than 40 severe neurological disorders caused by three-letter stretches of DNA that repeat consecutively. If longer than a certain threshold length, these sequences grow in length uncontrollably and lead to brain cell death in Huntington’s disease, and the breakdown of nerve fibers in Friedreich’s ataxia.
With AI, researchers predict the location of virtually any protein within a human cell

1 month ago | broadinstitute.org | Adam Zewe |fei chen |Caroline Uhler

A protein located in the wrong part of a cell can contribute to several diseases, such as Alzheimer’s, cystic fibrosis, and cancer. But there are about 70,000 different proteins and protein variants in a single human cell, and since scientists can typically only test for a handful in one experiment, it is extremely costly and time-consuming to identify proteins’ locations manually.
New study aims to uncover the genetics of anorexia and other eating disorders

1 month ago | broadinstitute.org | Allessandra DiCorato |Ben Neale |Mark Daly

A new direct-to-participant effort now underway is giving people the opportunity to participate in the largest and most diverse genetic study of anorexia nervosa and other eating disorders to date. Researchers at the Broad Institute Ben Neale and Mark Daly are co-leading the study, which allows people across the US to sign up to have their DNA analyzed as part of this effort.
Evolved gene editor inserts entire genes in human cells

1 month ago | broadinstitute.org | Allessandra DiCorato

Researchers from the Broad Institute and Columbia University have developed a way to insert entire healthy genes into human cells efficiently enough for potential therapeutic applications. It lays a foundation for gene-editing therapies for patients with different mutations that cause a genetic disease.
#WhyIScience Q&A: A systems biologist uses AI to understand how the genome controls cell fate

1 month ago | broadinstitute.org | Allessandra DiCorato

Growing up in the Sichuan province in China, Bo Xia was curious about the nature he saw around him: the creeks that ran through his hometown and its many animals and insects. In school, he loved imagining how molecules made up materials and whole organisms. He read about graphene in a textbook and was intrigued by how the material’s structure — a single layer of carbon atoms patterned like a honeycomb — granted it special electronic properties.
Potential Alzheimer’s disease therapeutic target identified in brain immune cells

2 months ago | broadinstitute.org | Brandon Chase

Since the 1990s, researchers have found several immune system molecules that act like “brakes” on immune responses, leading to a new class of cancer drugs. One of these “immune checkpoint” molecules, called Tim-3 has recently been linked to late-onset Alzheimer’s disease (AD), but its role in the brain was unknown until now.