Journal of Clinical Pathology

The Journal of Clinical Pathology is a respected medical journal that undergoes peer review, focusing on various facets of pathology. It is published by the BMJ Group in collaboration with the Association of Clinical Pathologists. The journal addresses diagnostic and research topics such as histopathology, virology, hematology, microbiology, cytopathology, chemical pathology, molecular pathology, forensic pathology, dermatopathology, neuropathology, and immunopathology. Each edition features a mix of content, including review articles, original research, brief reports, case studies, letters to the editor, and reviews of books.

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Articles

SARS-CoV-2 seropositivity amongst healthcare workers in South Africa during the Omicron wave: natural infection versus vaccination

Jan 16, 2025 | jcp.bmj.com | Daniel Hoffmann |Catherine M. Worsley |Tahir S Pillay |A Visser

AbstractAims Concerns over population-level immunity have been heightened with each successive wave of COVID-19, prompting questions about whether it is primarily derived from vaccination efforts or from previous natural infections with the virus. We wished to determine the seroprevalence of SARS-CoV-2 antibodies among healthcare workers (HCWs) in Pretoria (Tshwane), South Africa, and to establish whether they were derived from vaccination or natural infection.
Calcified chondroid mesenchymal neoplasm: a clinicopathological and molecular analysis

Jan 11, 2025 | jcp.bmj.com | Xiaolong Feng |Suxia Wang |Jiacong Wei |Weihua Li

Statistics from Altmetric.com Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways. View Full Text Read the full text or download the PDF:
SSTR2 positively associates with EGFR and predicts poor prognosis in nasopharyngeal carcinoma

Nov 20, 2024 | jcp.bmj.com | Yue Xu |Zihan Quan |Yuting Zhan |Haihua Wang

SSTR2 positively associates with EGFR and predicts poor prognosis in nasopharyngeal carcinoma Statistics from Altmetric.com Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
Molecular confirmation that fibrocartilaginous dysplasia is a variant of fibrous dysplasia

Aug 17, 2024 | jcp.bmj.com | Juan Zhou |Li Zhang |Xuling Su |Dingjun Hu

Aims Fibrocartilaginous dysplasia (FCD) is a subvariant of fibrous dysplasia (FD). This study aims to retrospectively elucidate the clinicopathological and separate genetic features of the cartilaginous and fibro-osseous components of FCD. Methods In total, 24 patients (14 men and 10 women) with FCD were included in our cohort. The diagnosis was confirmed morphologically and immunohistochemically, and genetic features were determined via Sanger sequencing.
Discerning clinicopathological features of congenital neutropenia syndromes: an approach to diagnostically challenging differential diagnoses

Aug 16, 2024 | jcp.bmj.com | Xenia Parisi |Jacob Bledsoe

General conceptsNeutropenia is generally defined as an absolute neutrophil count (ANC) <1500 cells/µL in adults and children over 1 year of age, but thresholds vary by age and ethnicity.7 8 The risk for infection correlates inversely with ANC. Severe neutropenia, an ANC<500 cells/µL, is associated with a high risk of overwhelming bacterial infection and mortality, even if optimally managed.
Enteroblastic gastric cancer subtype holds therapeutic clues

Aug 16, 2024 | jcp.bmj.com | Vikram Deshpande |Munita Bal

CARCINOMA Gastrointestinal Diseases Pathology Molecular In this issue of the Journal of Clinical Pathology, Pu and colleagues from the Nanjing University Medical School, China, report that NTRK gene alterations were enriched in gastric carcinoma with hepatoid or enteroblastic differentiation but not, as in the colon, dMMR-type gastric carcinomas.1 The study analysed 51 cases of EBV (Epstein-Barr virus)-associated gastric carcinomas, 94 cases of dMMR gastric carcinomas, 90 cases of gastric...
High-resolution melting assay for rapid, simultaneous detection of JAK2, MPL and CALR variants

Aug 16, 2024 | jcp.bmj.com | Christopher Sande |Guang Yang |Ayman Mohamed |Ben L Legendre

High-resolution melting assay for rapid, simultaneous detection of JAK2, MPL and CALR variants Statistics from Altmetric.com Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
Sudden cardiac death with morphologically normal heart: always do toxicology

Aug 16, 2024 | jcp.bmj.com | Davide Radaelli |Joseph Westaby |Gherardo Finocchiaro |Gianfranco Sinagra

Sudden cardiac death with morphologically normal heart: always do toxicology Statistics from Altmetric.com Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
The Impact of potential ‘confounders’ on the diagnostic sensitivity of circulating free DNA in management of FIT+ patients: a pilot study

Jul 18, 2024 | jcp.bmj.com | Mauro Scimia |Francesco Pepe |Gianluca Russo |Lucia Palumbo

The Impact of potential ‘confounders’ on the diagnostic sensitivity of circulating free DNA in management of FIT+ patients: a pilot study Statistics from Altmetric.com Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
Altered cytokeratin 5 expression in breast lobular myoepithelial cells

Jun 26, 2024 | jcp.bmj.com | Anqi Li |Miao Ruan |Xiaochun Fei |Haimin Xu

AbstractAims Cytokeratin 5 (CK5) is a surrogate maker of progenitor cells and early glandular and myoepithelial cells (MECs) in the breast, and CK5 expression in breast MECs varies from ducts to lobules, and from normal to diseased tissue. However, the mechanisms underlying immunophenotypic alterations of CK5 expression in MECs remain unclear.