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Jan 14, 2025 | 
digitalcommons.library.tmc.edu | Braden T. Tierney |James Versalovic |Alessio Fasano |Joseph F Petrosino
BACKGROUND: Oral microbial therapy has been studied as an intervention for a range of gastrointestinal disorders. Though research suggests that microbial exposure may affect the gastrointestinal system, motility, and host immunity in a pediatric population, data have been inconsistent, with most prior studies being in neither a randomized nor placebo-controlled setting.
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Sep 26, 2024 | 
nature.com | Braden T. Tierney |Kristina M. Babler |Bhavarth Shukla |Stephan C. Schürer |George M Church |Helena Solo-Gabriele | +1 more
AbstractWastewater is a geospatially- and temporally-linked microbial fingerprint of a given population, making it a potentially valuable tool for tracking public health across locales and time. Here, we integrate targeted and bulk RNA sequencing (N = 2238 samples) to track the viral, bacterial, and functional content over geospatially distinct areas within Miami Dade County, USA, from 2020-2022.
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Sep 14, 2024 | 
biorxiv.org | Lauren Mak |Braden T. Tierney |Cynthia Ronkowski |Rodolfo Toscan
AbstractMotivation: Computational analysis of large-scale metagenomics sequencing datasets have proven to be both incredibly valuable for extracting isolate-level taxonomic, and functional insights from complex microbial communities. However, due to an ever-expanding ecosystem of metagenomics-specific methods and file-formats, designing studies which implement seamless and scalable end-to-end workflows, and exploring the massive amounts of output data have become studies unto themselves.
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Jul 22, 2024 | 
nature.com | Lindsay Rutter |Henry Cope |Nathaniel J. Szewczyk |JangKeun Kim |Eliah G. Overbey |Braden T. Tierney | +4 more
AbstractCommon and rare alleles are now being annotated across millions of human genomes, and omics technologies are increasingly being used to develop health and treatment recommendations. However, these alleles have not yet been systematically characterized relative to aerospace medicine. Here, we review published alleles naturally found in human cohorts that have a likely protective effect, which is linked to decreased cancer risk and improved bone, muscular, and cardiovascular health.
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Jun 11, 2024 | 
nature.com | Eliah G. Overbey |JangKeun Kim |Braden T. Tierney |Jiwoon Park |Deena Najjar |Remi Klotz | +30 more
AbstractSpaceflight induces molecular, cellular, and physiological shifts in astronauts and poses myriad biomedical challenges to the human body, which are becoming increasingly relevant as more humans venture into space1-6. Yet, current frameworks for aerospace medicine are nascent and lag far behind advancements in precision medicine on Earth, underscoring the need for rapid development of space medicine databases, tools, and protocols.
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Jun 11, 2024 | 
nature.com | Christopher Jones |Eliah G. Overbey |Cem Meydan |Braden T. Tierney |Jiwoon Park |Theodore Nelson | +14 more
AbstractHuman spaceflight has historically been managed by government agencies, such as in the NASA Twins Study1, but new commercial spaceflight opportunities have opened spaceflight to a broader population.
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Jun 11, 2024 | 
nature.com | Christopher Mason |James Green |Jordan Baechle |Mathias Basner |Susan Bailey |Joseph Borg | +34 more
AbstractThe recent acceleration of commercial, private and multi-national spaceflight has created an unprecedented level of activity in low Earth orbit, concomitant with the largest-ever number of crewed missions entering space and preparations for exploration-class (lasting longer than one year) missions. Such rapid advancement into space from many new companies, countries and space-related entities has enabled a ‘second space age’.
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Jun 10, 2024 | 
nature.com | Eliah G. Overbey |JangKeun Kim |Braden T. Tierney |Remi Klotz |Irina Matei |Bader Shirah | +2 more
AbstractThe SpaceX Inspiration4 mission provided a unique opportunity to study the impact of spaceflight on the human body. Biospecimen samples were collected from four crew members longitudinally before (Launch: L-92, L-44, L-3 days), during (Flight Day: FD1, FD2, FD3), and after (Return: R + 1, R + 45, R + 82, R + 194 days) spaceflight, spanning a total of 289 days across 2021-2022.
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Jun 10, 2024 | 
nature.com | JangKeun Kim |Christopher R Chin |Tammy Liu |Irina Matei |Cem Meydan |Masafumi Muratani | +7 more
AbstractIt is now widely recognised that the environment in space activates a diverse set of genes involved in regulating fundamental cellular pathways. This includes the activation of genes associated with blood homeostasis and erythropoiesis, with a particular emphasis on those involved in globin chain production.
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Jun 10, 2024 | 
nature.com | Jiwoon Park |Eliah G. Overbey |JangKeun Kim |Braden T. Tierney |Deena Najjar |Sarah Church | +4 more
AbstractSpaceflight can change metabolic, immunological, and biological homeostasis and cause skin rashes and irritation, yet the molecular basis remains unclear. To investigate the impact of short-duration spaceflight on the skin, we conducted skin biopsies on the Inspiration4 crew members before (L-44) and after (R + 1) flight.
