Espen Molden

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Polygenic overlap with granulocyte counts identifies novel loci for clozapine metabolism and clozapine-induced agranulocytosis - Neuropsychopharmacology

Jan 17, 2025 | nature.com | Elise Koch |Nadine Staples Parker |Siobhan K. Lock |Oleksandr Frei |Anders M. Dale |Srdjan Djurovic | +1 more

AbstractWhile clozapine is the most effective antipsychotic drug, its use is limited due to hematological adverse effects involving the reduction of granulocyte counts with potential life-threatening agranulocytosis. It is not yet possible to predict or prevent the risk of agranulocytosis, and the mechanisms are unknown but likely related to clozapine metabolism. Genome-wide association studies (GWASs) of clozapine metabolism and clozapine-induced agranulocytosis have identified few genetic loci.
Polygenic liability for antipsychotic dosage and polypharmacy - a real-world registry and biobank study - Neuropsychopharmacology

Jan 5, 2024 | nature.com | Elise Koch |Nils Eiel Steen |Olav B. Smeland |Srdjan Djurovic |Espen Molden

AbstractGenomic prediction of antipsychotic dose and polypharmacy has been difficult, mainly due to limited access to large cohorts with genetic and drug prescription data.

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