Nils Eiel Steen

Aug 21, 2024 | nature.com | Milin Kim |Esten Leonardsen |Geir Selbæk |Nils Eiel Steen |Olav B. Smeland |Geneviève Richard | +4 more

AbstractThe cerebellum is linked to motor coordination, cognitive and affective processing, in addition to a wide range of clinical illnesses. To enable robust quantification of individual cerebellar anatomy relative to population norms, we mapped the normative development and aging of the cerebellum across the lifespan using brain scans of >54,000 participants. We estimated normative models at voxel-wise spatial precision, enabling integration with cerebellar atlases.

Apr 16, 2024 | nature.com | Francesco Bettella |Claudia Barth |Nils Eiel Steen |Emanuel Schwarz |Dan Stein |Ole A. Andreassen | +2 more

AbstractOxytocin is a neuropeptide associated with both psychological and somatic processes like parturition and social bonding. Although oxytocin homologs have been identified in many species, the evolutionary timeline of the entire oxytocin signaling gene pathway has yet to be described.

Jan 5, 2024 | nature.com | Elise Koch |Nils Eiel Steen |Olav B. Smeland |Srdjan Djurovic |Espen Molden

AbstractGenomic prediction of antipsychotic dose and polypharmacy has been difficult, mainly due to limited access to large cohorts with genetic and drug prescription data.

May 5, 2023 | nature.com | Timothy Hughes |Nils Eiel Steen |Ingrid Melle |Srdjan Djurovic |Ole A. Andreassen |Anja Torsvik | +1 more

AbstractSchizophrenia (SCZ) and bipolar disorder (BD) share clinical characteristics, genetic susceptibility, and immune alterations. We aimed to identify differential transcriptional patterns in peripheral blood cells of patients with SCZ or BD versus healthy controls (HC). We analyzed microarray-based global gene expression data in whole blood from a cohort of SCZ (N = 329), BD (N = 203) and HC (N = 189).