Ewan R Pearson

Oct 24, 2024 | nature.com | Daniel E. Coral |Alexander Gieswinkel |Kan Wang |Marinella Temprosa |Jose Manuel Fernández-Real |M. Kamran Ikram | +11 more

AbstractObesity and cardiometabolic disease often, but not always, coincide. Distinguishing subpopulations within which cardiometabolic risk diverges from the risk expected for a given body mass index (BMI) may facilitate precision prevention of cardiometabolic diseases. Accordingly, we performed unsupervised clustering in four European population-based cohorts (N ≈ 173,000).

Oct 5, 2023 | nature.com | Robin Beaumont |Christopher Flatley |Marc Vaudel |JING CHEN |Gunn-Helen Moen |Line Skotte | +52 more

AbstractA well-functioning placenta is essential for fetal and maternal health throughout pregnancy. Using placental weight as a proxy for placental growth, we report genome-wide association analyses in the fetal (n = 65,405), maternal (n = 61,228) and paternal (n = 52,392) genomes, yielding 40 independent association signals. Twenty-six signals are classified as fetal, four maternal and three fetal and maternal. A maternal parent-of-origin effect is seen near KCNQ1.

Oct 4, 2023 | nature.com | Maggie A. Stanislawski |Ewan R Pearson |John Dennis

AbstractA precision medicine approach in type 2 diabetes requires the identification of clinical and biological features that are reproducibly associated with differences in clinical outcomes with specific anti-hyperglycaemic therapies. Robust evidence of such treatment effect heterogeneity could support more individualized clinical decisions on optimal type 2 diabetes therapy.

Aug 21, 2023 | nature.com | Andrew Brown |Mun-Gwan Hong |Robert Caiazzo |Giuseppe Giordano |Mark Haid |Torben Frøstrup Hansen | +17 more

AbstractWe evaluate the shared genetic regulation of mRNA molecules, proteins and metabolites derived from whole blood from 3029 human donors. We find abundant allelic heterogeneity, where multiple variants regulate a particular molecular phenotype, and pleiotropy, where a single variant associates with multiple molecular phenotypes over multiple genomic regions.

May 3, 2023 | nature.com | Roderick C. Slieker |Eleni Georgiadou |Giuseppe Giordano |Emma Ahlqvist |Ashfaq Ansari Ali |Karina Banasik | +22 more

Discovery cohorts Summary statistics of lipidomic, proteomic and metabolomic data is available from a Shiny dashboard available from: https://rhapdata-app.vital-it.ch. The generated metabolomic, lipidomic and proteomic data in DCS, GoDARTS and ANDIS are considered sensitive patient data and can therefore not be publicly available in compliance with the European privacy regulations governed by GDPR and according to limitations included in the informed consents signed by the study participants.