Hailiang Huang

Jul 14, 2024 | medrxiv.org | Justin Tubbs |Yu Chen |Rui Duan |Hailiang Huang

H.H. received consultancy fees from Ono Pharmaceutical and honorarium from Xian Janssen Pharmaceutical. The other authors declare no competing interests. J.D.T is supported by the Mass General Brigham Training Program in Precision and Genomic Medicine (T32HG010464). R.D. is supported by National Institute of General Medical Sciences (NIGMS) R01GM148494.

Feb 25, 2024 | nature.com | Max Lam |Jimmy Liu |Daniel F Levey |Joel Gelernter |Murray B. Stein |Ellen A. Tsai | +3 more

AbstractNearly two hundred common-variant depression risk loci have been identified by genome-wide association studies (GWAS). However, the impact of rare coding variants on depression remains poorly understood. Here, we present whole-exome sequencing analyses of depression with seven different definitions based on survey, questionnaire, and electronic health records in 320,356 UK Biobank participants.

Jan 4, 2024 | nature.com | Tzu-Ting Chen |Jaeyoung Kim |Max Lam |Sang-Hyuk Jung |Soyeon Kim |Injeong Shim | +9 more

AbstractEducational attainment (EduYears), a heritable trait often used as a proxy for cognitive ability, is associated with various health and social outcomes. Previous genome-wide association studies (GWASs) on EduYears have been focused on samples of European (EUR) genetic ancestries. Here we present the first large-scale GWAS of EduYears in people of East Asian (EAS) ancestry (n = 176,400) and conduct a cross-ancestry meta-analysis with EduYears GWAS in people of EUR ancestry (n = 766,345).

May 25, 2023 | nature.com | Chia-Yen Chen |Max Lam |Tarjinder Singh |Jimmy Liu |Aarno Palotie |Ellen A. Tsai | +4 more

AbstractCompelling evidence suggests that human cognitive function is strongly influenced by genetics. Here, we conduct a large-scale exome study to examine whether rare protein-coding variants impact cognitive function in the adult population (n = 485,930). We identify eight genes (ADGRB2, KDM5B, GIGYF1, ANKRD12, SLC8A1, RC3H2, CACNA1A and BCAS3) that are associated with adult cognitive function through rare coding variants with large effects.