-
Jan 6, 2025 | 
onlinelibrary.wiley.com | James WIlson |James Wilson |Jarl Giske |Culum Brown
1 Introduction In the four or five decades since the creation of exclusive economic zones, global marine fish landings have stabilised (FAO 2022) but with ‘a gradual transition from long-lived, high trophic level, piscivorous bottom fish toward short-lived, low trophic level invertebrates and planktivorous pelagic fish’ (Pauly et al. 1998). As Pauly and others (Frank et al. 2005; Howarth et al. 2013; Myers and Worm 2005; Steneck et al. 2011; Jackson et al. 2001; Worm et al.
-
Dec 20, 2024 | 
mdpi.com | James WIlson |James Wilson
Altmetric announcement Help format_quote Cite thumb_up ... Endorse Need Help? Find support for a specific problem in the support section of our website. Please let us know what you think of our products and services. Visit our dedicated information section to learn more about MDPI.
-
Dec 5, 2024 | 
nature.com | Elias Allara |Steven Bell |Dipender Gill |Liam Gaziano |Feiyi Wang |Vinicius Tragante | +30 more
AbstractIron homoeostasis is tightly regulated, with hepcidin and soluble transferrin receptor (sTfR) playing significant roles. However, the genetic determinants of these traits and the biomedical consequences of iron homoeostasis variation are unclear. In a meta-analysis of 12 cohorts involving 91,675 participants, we found 43 genomic loci associated with either hepcidin or sTfR concentration, of which 15 previously unreported.
-
Dec 5, 2024 | nature.com | Elias Allara |Steven Bell |Dipender Gill |Liam Gaziano |Feiyi Wang |Vinicius Tragante | +30 more
AbstractIron homoeostasis is tightly regulated, with hepcidin and soluble transferrin receptor (sTfR) playing significant roles. However, the genetic determinants of these traits and the biomedical consequences of iron homoeostasis variation are unclear. In a meta-analysis of 12 cohorts involving 91,675 participants, we found 43 genomic loci associated with either hepcidin or sTfR concentration, of which 15 previously unreported.
-
Dec 5, 2024 | nature.com | Elias Allara |Steven Bell |Dipender Gill |Liam Gaziano |Feiyi Wang |Vinicius Tragante | +30 more
AbstractIron homoeostasis is tightly regulated, with hepcidin and soluble transferrin receptor (sTfR) playing significant roles. However, the genetic determinants of these traits and the biomedical consequences of iron homoeostasis variation are unclear. In a meta-analysis of 12 cohorts involving 91,675 participants, we found 43 genomic loci associated with either hepcidin or sTfR concentration, of which 15 previously unreported.
-
Nov 21, 2024 | 
nature.com | Xuexiang Han |Mohamad-Gabriel Alameh |Rakan El-Mayta |Kelsey Swingle |Junchao Xu |Ningqiang Gong | +5 more
AbstractIonizable lipids largely determine the biocompatibility of lipid nanoparticles (LNPs) and the efficacy for mRNA delivery. Rational design and combinatorial synthesis have led to the development of potent and biodegradable ionizable lipids, yet methodologies for the stepwise optimization of ionizable lipid structure are lacking.
-
Nov 6, 2024 | 
advisorpedia.com | James WIlson |James Wilson
Many areas of life benefit from cumulative knowledge: knowledge that increases over time, with new knowledge adding to what was known previously. Some other areas, like investing and personal finance, are impacted mostly by cyclical knowledge: knowledge that repeats itself over and over, often with the same errors that were observed in the past.
-
Oct 15, 2024 | 
nist.gov | Eric Holterman |Dennis Brandl |Benjamin Standfield |James WIlson |James Wilson
Eric Holterman, Dennis Brandl, Benjamin Standfield, James Wilson, Nima Yazdanpanah, Jim Fritz, Michael Corsello, Barbara Boyan, John Hagwood, Charles Ditchendorf, William Sobel, Lorin Sodell, This work presents and catalyzes support for a technology roadmap to improve the resilience and capacity of the US manufacturing supply chain through Digital Thread technology.
-
Oct 1, 2024 | 
nature.com | Lulu Xue |Gan Zhao |Ningqiang Gong |Xuexiang Han |Zebin Xiao |Junchao Xu | +11 more
AbstractSystemic delivery of messenger RNA (mRNA) for tissue-specific targeting using lipid nanoparticles (LNPs) holds great therapeutic potential. Nevertheless, how the structural characteristics of ionizable lipids (lipidoids) impact their capability to target cells and organs remains unclear.
-
Sep 6, 2024 | 
onlinelibrary.wiley.com | Milton Fabian Suarez-Ortegon |Stela McLachlan |Jose Manuel Fernández-Real |James WIlson |James Wilson
1 INTRODUCTION Increased body iron stores, estimated by serum ferritin (SF) levels, are associated with higher risk of type 2 diabetes (T2D),1, 2 although their relationship with cardiovascular disease (CVD) is unclear.3 Ferritin is an intracellular protein with a significant capacity to uptake and store iron ions, with each molecule capable of sequestering approximately 3000 iron atoms.
