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1 month ago | 
science.org | John K. Mich |Itay Raphael |Raphaël Porret |Matthew Lacorcia |Pushpak Bhattacharjee |Abby Foster | +6 more
Editor’s summaryβ cell antigen–specific CD4+ T cell responses promote autoimmune destruction of insulin-producing pancreatic β cells. The ability to easily quantify the extent of such responses could potentially benefit the management of patients with or at risk of type 1 diabetes. Lacorcia et al. show that autoreactive CD4+ T cell responses to C-peptide can be accurately measured by detecting secreted IL-2.
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Nov 29, 2024 | 
lesswrong.com | John Wentworth |Gene Smith
TLDR: LessWrong + Lighthaven need about $3M for the next 12 months. Donate here, or send me an email, DM or signal message (+1 510 944 3235) if you want to support what we do. Donations are tax-deductible in the US. Reach out for other countries, we can likely figure something out. We have big plans for the next year, and due to a shifting funding landscape we need support from a broader community more than in any previous year.
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Sep 3, 2024 | 
onlinelibrary.wiley.com | Joanna Y. Gong |John Wentworth |Immunity Walter
Letter to the Editor Resolution of symptoms of binge eating disorder associated with semaglutide treatment for obesity and type 1 diabetes Joanna Y. Gong, Joanna Y. Gong Department of Diabetes and Endocrinology, The Royal Melbourne Hospital, Melbourne, Victoria, Australia Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia Department of Medicine (RMH), The Royal Melbourne Hospital, Melbourne, Victoria, AustraliaSearch for more papers by this authorJohn M. Wentworth, John M.
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Aug 14, 2024 | 
tvtropes.org | Sheldon Mayer |Gardner Fox |John Wentworth
A list of characters who have been members of the Justice Society of America or appeared in one of their titular series over the years. <!—index—> For their villains and antagonists, check the page here. <!—/index—><!—index—> open/close all folders JSA Members On Other Pages Doctor Mid-Nite I (Charles McNider) " There are no dark corners for evil to hide in...
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Jul 25, 2024 | 
lesswrong.com | John Wentworth
This is an edited transcription of the final presentation I gave for the AI safety camp cohort of early 2024. It describes some of what the project is aiming for, and some motivation. Here's a link to the slides. See this post for a more detailed and technical overview of the problem. This is the presentation for the project that is described as "does sufficient optimization imply agent structure".
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May 6, 2024 | 
lesswrong.com | Daniel Filan |John Wentworth |Evan Hubinger |Vanessa Kosoy’s work
What’s going on with deep learning? What sorts of models get learned, and what do the learning dynamics? Singular learning theory is a theory of Bayesian statistics broad enough in scope to encompass deep neural networks that may help answer these questions. In this episode, I speak with Daniel Murfet about this research program and what it tells us. Topics we discuss: What is singular learning theory?
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Apr 29, 2024 | 
lesswrong.com | John Wentworth |Scott Garrabrant
In Clarifying the Agent-Like Structure Problem (2022), John Wentworth describes a hypothetical instance of what he calls a selection theorem. In Scott Garrabrant's words, the question is, does agent-like behavior imply agent-like architecture? That is, if we take some class of behaving things and apply a filter for agent-like behavior, do we end up selecting things with agent-like architecture (or structure)? Of course, this question is heavily under-specified.
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Apr 6, 2024 | 
nature.com | Jamie Felton |S. Alice Long |Suna Onengut-Gumuscu |Stephen S. Rich |dianna perez |Linda A. DiMeglio | +2 more
AbstractIslet autoantibodies form the foundation for type 1 diabetes (T1D) diagnosis and staging, but heterogeneity exists in T1D development and presentation. We hypothesized that autoantibodies can identify heterogeneity before, at, and after T1D diagnosis, and in response to disease-modifying therapies.
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Mar 21, 2024 | 
westlinntidings.com | John Wentworth
Recently, three former patients of Dr. David Farley wrote an op-ed criticizing the investigation and prosecution of his criminal case. Because I have spent my career fighting for women who experience violence and have a commitment to transparency, I am replying to set the record straight. Claim 1: More than 200 women filed complaints with WLPD, but fewer than a quarter testified at grand jury.
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Dec 6, 2023 | 
nejm.org | Michaela Waibel |John Wentworth |Michelle P. So |Jennifer J. Couper
AbstractJanus kinase (JAK) inhibitors, including baricitinib, block cytokine signaling and are effective disease-modifying treatments for several autoimmune diseases. Whether baricitinib preserves β-cell function in type 1 diabetes is unclear. In this phase 2, double-blind, randomized, placebo-controlled trial, we assigned patients with type 1 diabetes diagnosed during the previous 100 days to receive baricitinib (4 mg once per day) or matched placebo orally for 48 weeks.
