Linbo Wang

Nov 18, 2024 | nature.com | Yu Guo |Linbo Wang |Jujiao Kang |Qiang Dong |Jianfeng Feng |Wei Cheng

AbstractPathophysiological evolutions in early-stage Alzheimer’s disease (AD) are not well understood. We used data of 2923 Olink plasma proteins from 51,296 non-demented middle-aged adults. During a follow-up of 15 years, 689 incident AD cases occurred. Cox-proportional hazard models were applied to identify AD-associated proteins in different time intervals. Through linking to protein categories, changing sequences of protein z-scores can reflect pathophysiological evolutions.

Aug 6, 2024 | nature.com | Jia You |Wei Cheng |Xiaojun Xu |Minming Zhang |Linbo Wang

AbstractParkinson’s disease (PD) exhibits heterogeneity in terms of symptoms and prognosis, likely due to diverse neuroanatomical alterations. This study employs a contrastive deep learning approach to analyze Magnetic Resonance Imaging (MRI) data from 932 PD patients and 366 controls, aiming to disentangle PD-specific neuroanatomical alterations.

Jun 12, 2024 | preprints.org | Linbo Wang

PreprintHypothesisVersion 1This version is not peer-reviewedVersion 1: Received: 11 June 2024 / Approved: 11 June 2024 / Online: 12 June 2024 (14:52:48 CEST)Wang, L. The Driving Force of Natural Selection: Maximizing Entropy Production Rates. Preprints 2024, 2024060783. https://doi.org/10.20944/preprints202406.0783.v1Wang, L. The Driving Force of Natural Selection: Maximizing Entropy Production Rates. Preprints 2024, 2024060783.

Oct 16, 2023 | bmccancer.biomedcentral.com | Qinchuan Wang |fei chen |Aihua Huang |Cong Chen |Yi Lu |Linbo Wang | +3 more

A total of 646 patients were included for the final analysis, with a median follow-up of 5.0 years (ranging from 0.4 to 18.0 years). The pretreatment characteristics, treatment strategies, as well as response and follow-up information of patients are summarized in Table 1. The median age of the cohort at diagnosis was 49 years old (ranging from 22 to 84). After NAC, 118 patients (18.2%) in the cohort experienced pCR, whereas 528 (81.7%) exhibited residual disease.

May 18, 2023 | n.neurology.org | Linbo Wang |Cheng Zhou |Wei Zhang |Minming Zhang

REQUIREMENTSYou must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information. Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.