Linbo Wang

Nov 18, 2024 | nature.com | Yu Guo |Linbo Wang |Jujiao Kang |Qiang Dong |Jianfeng Feng |Wei Cheng

AbstractPathophysiological evolutions in early-stage Alzheimer’s disease (AD) are not well understood. We used data of 2923 Olink plasma proteins from 51,296 non-demented middle-aged adults. During a follow-up of 15 years, 689 incident AD cases occurred. Cox-proportional hazard models were applied to identify AD-associated proteins in different time intervals. Through linking to protein categories, changing sequences of protein z-scores can reflect pathophysiological evolutions.

Aug 6, 2024 | nature.com | Jia You |Wei Cheng |Xiaojun Xu |Minming Zhang |Linbo Wang

AbstractParkinson’s disease (PD) exhibits heterogeneity in terms of symptoms and prognosis, likely due to diverse neuroanatomical alterations. This study employs a contrastive deep learning approach to analyze Magnetic Resonance Imaging (MRI) data from 932 PD patients and 366 controls, aiming to disentangle PD-specific neuroanatomical alterations.

Jun 12, 2024 | preprints.org | Linbo Wang

PreprintHypothesisVersion 1This version is not peer-reviewedVersion 1: Received: 11 June 2024 / Approved: 11 June 2024 / Online: 12 June 2024 (14:52:48 CEST)Wang, L. The Driving Force of Natural Selection: Maximizing Entropy Production Rates. Preprints 2024, 2024060783. https://doi.org/10.20944/preprints202406.0783.v1Wang, L. The Driving Force of Natural Selection: Maximizing Entropy Production Rates. Preprints 2024, 2024060783.

Oct 16, 2023 | bmccancer.biomedcentral.com | Qinchuan Wang |fei chen |Aihua Huang |Cong Chen |Yi Lu |Linbo Wang | +3 more

A total of 646 patients were included for the final analysis, with a median follow-up of 5.0 years (ranging from 0.4 to 18.0 years). The pretreatment characteristics, treatment strategies, as well as response and follow-up information of patients are summarized in Table 1. The median age of the cohort at diagnosis was 49 years old (ranging from 22 to 84). After NAC, 118 patients (18.2%) in the cohort experienced pCR, whereas 528 (81.7%) exhibited residual disease.