Lisa M. Bramer

Jan 19, 2025 | nature.com | Lisa M. Bramer |Ernesto S. Nakayasu |Michael J MacCoss |Thomas Metz

AbstractThe deployment of liquid chromatography-mass spectrometry-based plasma proteomics experiments in a large cohort is sparse, leading to a lack of data available for benchmarking, method development or validation. Comprised of 6,426 plasma analyses, The Environmental Determinants of Diabetes in the Young (TEDDY) proteomics validation study constitutes one of the largest targeted proteomics experiments in the literature to date.

Dec 4, 2024 | nature.com | James M. Fulcher |Hugh Mitchell |David Degnan |Lisa M. Bramer |Ronald Moore |Wei-Jun Qian | +1 more

AbstractSingle-cell multiomics provides comprehensive insights into gene regulatory networks, cellular diversity, and temporal dynamics. Here, we introduce nanoSPLITS (nanodroplet SPlitting for Linked-multimodal Investigations of Trace Samples), an integrated platform that enables global profiling of the transcriptome and proteome from same single cells via RNA sequencing and mass spectrometry-based proteomics, respectively.

Jan 31, 2024 | nature.com | Ruonan Wu |Nathalie Muñoz |Aivett Bilbao |Rosalie K. Chu |Carrie D. Nicora |Daniel Orton | +7 more

AbstractThe leaf-cutter ant fungal garden ecosystem is a naturally evolved model system for efficient plant biomass degradation. Degradation processes mediated by the symbiotic fungus Leucoagaricus gongylophorus are difficult to characterize due to dynamic metabolisms and spatial complexity of the system.

Oct 17, 2023 | dx.doi.org | David Degnan |Lisa M. Bramer |Lee Ann McCue

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