-
Nov 12, 2024 | 
publications.ersnet.org | Beenish Iqbal |Eihab O. Bedawi |Najib M. Rahman
IntroductionWe start with a scenario. A patient has been given 3–4 months' life expectancy and has to make a choice between two treatments for their recurring malignant pleural effusion (MPE): one which requires hospital admission for 4–5 days and still might not work versus a “one-off” procedure with home drainage. Which one sounds better?
-
Oct 23, 2024 | 
bmj.com | Najib M. Rahman |James Ware |Rupert Woolley
Rupert Woolley, Najib Rahman, James Ware Woolley R, Rahman N, Ware J. John Matthew Wrightson BMJ 2024; 387 :q2290 doi:10.1136/bmj.q2290
-
Jun 27, 2024 | 
bmjopenrespres.bmj.com | Catherine Henshall |Paul Dawson |Najib M. Rahman |Hannah Ball
Understanding clinical decision-making in mesothelioma care: a mixed methods study Statistics from Altmetric.com Request Permissions If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
-
Apr 1, 2024 | 
nature.com | Pablo F. Céspedes |Uzi Gileadi |Zhu Liang |Fei Gao |Nikolaos Kanellakis |Yi-Ling Chen | +7 more
AbstractCancer remains one of the leading causes of mortality worldwide, leading to increased interest in utilizing immunotherapy strategies for better cancer treatments. In the past decade, CD103+ T cells have been associated with better clinical prognosis in patients with cancer. However, the specific immune mechanisms contributing toward CD103-mediated protective immunity remain unclear.
-
Feb 23, 2024 | 
nature.com | Joseph F Standing |Laura Buggiotti |Claire Smith |Theo Sanderson |Fiona Ashford |Adrian Shields | +13 more
AbstractViral clearance, antibody response and the mutagenic effect of molnupiravir has not been elucidated in at-risk populations. Non-hospitalised participants within 5 days of SARS-CoV-2 symptoms randomised to receive molnupiravir (n = 253) or Usual Care (n = 324) were recruited to study viral and antibody dynamics and the effect of molnupiravir on viral whole genome sequence from 1437 viral genomes. Molnupiravir accelerates viral load decline, but virus is detectable by Day 5 in most cases.
-
Oct 17, 2023 | 
thorax.bmj.com | Mark Roberts |Najib M. Rahman |Nick A. Maskell |Anna C Bibby
After an initial screening to determine relevance to the clinical questions, each paper was assessed to determine if it addressed:The clinical question population. The index test and reference standard (for diagnostic accuracy questions), the intervention and comparator (for intervention questions), or the exposure and referent (for prognostic questions). The study type(s) defined in the clinical question protocol; andThe clinical question outcome(s).
-
Oct 1, 2023 | 
spcare.bmj.com | Rebecca Ferris |Andrew Wilson |Najib M. Rahman |Chloe Twose
AbstractIntroduction Malignant pleural effusions (MPEs) commonly occur in patients with advanced cancer. Drainage of fluid is used to relieve symptoms and improve quality of life. Objective To improve our understanding of how therapeutic aspiration affects symptoms and activities in patients with MPE.
-
Aug 8, 2023 | 
thorax.bmj.com | Mark Roberts |Najib M. Rahman |Nick A. Maskell |Anna C Bibby
Mark E Roberts1, http://orcid.org/0000-0003-1195-1680Najib M Rahman2,3,4, Nick A Maskell5, Anna C Bibby5, http://orcid.org/0000-0003-2972-6641Kevin G Blyth6,7, http://orcid.org/0000-0002-0480-7819John P Corcoran8, Anthony Edey9, http://orcid.org/0000-0003-4066-5253Matthew Evison10, http://orcid.org/0000-0002-0060-9671Duneesha de Fonseka11, Rob Hallifax12, Susan Harden13, Iain Lawrie14, Eric Lim15, David McCracken16, Rachel Mercer17, http://orcid.org/0000-0002-5903-3005Eleanor K Mishra18,...
-
Aug 3, 2023 | 
thorax.bmj.com | Mark Roberts |Najib M. Rahman |Nick A. Maskell |Anna C Bibby
Other areas of clinical importance not covered by the clinical questionsSome areas of clinical importance which have not been covered by the guideline clinical questions are included below as a guide for clinicians. PregnancyPneumothorax in pregnancy can pose risks to the mother and foetus.
-
Apr 4, 2023 | 00030-4/abstract?rss=yes&sz=64)
thelancet.com | Amit Chopra |Marc A. Judson |Najib M. Rahman |Peter Doelken
A penetrating needle injury to the lung does not cause extravasation of the air into the pleural space in most cases. The rate of clinically significant pneumothorax is only 7% after CT-guided transthoracic lung biopsy during which the biopsy needle usually traverses the lung parenchyma one or more times.Despite this well known benign outcome from needle penetration of the lung, it is underappreciated that this phenomenon has profound implications for the management of pneumothorax.
