Pravesh Parekh

1 month ago | nature.com | Pravesh Parekh |Sara Stinson |Maria Koromina |Jaroslav Rokicki |Ida E Sønderby |Nadine Staples Parker | +11 more

AbstractMetabolites in plasma form biosignatures of a range of common complex human diseases. Discovering variants with pleiotropic effects across metabolites can reveal underlying biological mechanisms. We therefore performed uni- and multivariate genome-wide association studies (GWAS) on 249 circulating metabolic markers across 328,006 UK Biobank and Estonian Biobank participants.

Oct 1, 2024 | nature.com | Shahram Bahrami |Kaja Nordengen |Olav B. Smeland |Nadine Staples Parker |Pravesh Parekh |Torbjørn Elvsåshagen | +4 more

AbstractThe basal ganglia are subcortical brain structures involved in motor control, cognition, and emotion regulation. We conducted univariate and multivariate genome-wide association analyses (GWAS) to explore the genetic architecture of basal ganglia volumes using brain scans obtained from 34,794 Europeans with replication in 4,808 white and generalization in 5,220 non-white Europeans.

May 10, 2024 | biorxiv.org | Diana Smith |Pravesh Parekh |Joseph E. Kennedy |Robert Loughnan

AbstractThe relative contributions of genetic variation and experience in shaping the morphology of the adolescent brain are not fully understood. Using longitudinal data from 11,665 subjects in the ABCD Study®, we fit vertex-wise variance components including family effects, genetic effects, and subject-level effects using a computationally efficient framework.

Apr 18, 2024 | medrxiv.org | Pravesh Parekh |Laura Hegemann |Viktoria Birkenas |Nora Refsum Bakken

Prof. Andreassen has received speaker fees from Lundbeck, Janssen, Otsuka, and Sunovion and is aconsultant to Cortechs.ai. and Precision Health. None of the remaining authors have any conflicts ofinterest.

Jan 29, 2024 | onlinelibrary.wiley.com | Pravesh Parekh |Chun Chieh Fan |Oleksandr Frei |Clare Palmer

1 INTRODUCTION As neuroimaging studies have moved to large sample sizes, the size of datasets and the complexity of relationships among observations within these datasets pose several challenges to neuroimaging analysis. For example, in the Adolescent Brain Cognitive DevelopmentSM Study (ABCD Study®) (https://abcdstudy.org), the inclusion of twins and siblings, in addition to a longitudinal design, make it necessary to simultaneously consider multiple correlations among observations.