Shahram Bahrami

Oct 1, 2024 | nature.com | Shahram Bahrami |Kaja Nordengen |Olav B. Smeland |Nadine Staples Parker |Pravesh Parekh |Torbjørn Elvsåshagen | +4 more

AbstractThe basal ganglia are subcortical brain structures involved in motor control, cognition, and emotion regulation. We conducted univariate and multivariate genome-wide association analyses (GWAS) to explore the genetic architecture of basal ganglia volumes using brain scans obtained from 34,794 Europeans with replication in 4,808 white and generalization in 5,220 non-white Europeans.

Sep 14, 2023 | nature.com | Shahram Bahrami |Oleksandr Frei |Guy Hindley |Anders M. Dale |Srdjan Djurovic |Sigrun Hope

AbstractAutism spectrum disorder (ASD) is a highly heritable condition with a large variation in cognitive function. Here we investigated the shared genetic architecture between cognitive traits (intelligence (INT) and educational attainment (EDU)), and risk loci jointly associated with ASD and the cognitive traits. We analyzed data from genome-wide association studies (GWAS) of INT (n = 269,867), EDU (n = 766,345) and ASD (cases n = 18,381, controls n = 27,969).

Sep 1, 2023 | nature.com | Shahram Bahrami |Guy Hindley |Olav B. Smeland |Oleksandr Frei |Chun C. Fan |Srdjan Djurovic | +2 more

AbstractAnorexia nervosa (AN) is a heritable eating disorder (50–60%) with an array of commonly comorbid psychiatric disorders and related traits. Although significant genetic correlations between AN and psychiatric disorders and related traits have been reported, their shared genetic architecture is largely understudied.

Jun 26, 2023 | nature.com | Guy Hindley |Alexey Shadrin |Shahram Bahrami |Børge Holen |Thomas Bjella |Gail Davies | +5 more

Author notesThese authors contributed equally: Guy Hindley, Alexey A. Shadrin. Authors and AffiliationsNORMENT Centre, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, NorwayGuy Hindley, Alexey A. Shadrin, Dennis van der Meer, Nadine Parker, Weiqiu Cheng, Kevin S. O’Connell, Shahram Bahrami, Aihua Lin, Naz Karadag, Børge Holen, Thomas Bjella, Torill Ueland, Olav B. Smeland, Oleksandr Frei & Ole A.