Journal of Medicinal Chemistry

The Journal of Medicinal Chemistry is a respected peer-reviewed journal that focuses on advancements in the field of medicinal chemistry. It is published by the American Chemical Society and has been in circulation since 1959, originally starting as the Journal of Medicinal and Pharmaceutical Chemistry before adopting its current title in 1963. The journal is currently led by editors-in-chief Gunda I. Georg from the University of Minnesota and Shaomeng Wang from the University of Michigan, who took over from Philip S. Portoghese in 2012. Portoghese had a long tenure as editor-in-chief, serving from 1972 until 2011. As per the Journal Citation Reports, the journal achieved an impact factor of 5.447 in 2014, placing it 3rd among 59 journals in the "Chemistry, Medicinal" category.

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Articles

Mg-Ion-Promoted Resistance and Regeneration Ability of Cu/SSZ-13 Catalysts against Phosphorus Poisoning for Selective Catalytic Reduction of NOx

3 days ago | pubs.acs.org | Xuan Tang |Yanzhao Gao |Wenbo Li |Sheng Dai
The Science of Polymer Chemical Recycling Catalysis: Uncovering Kinetic and Thermodynamic Linear Free Energy Relationships

5 days ago | pubs.acs.org | Thomas McGuire |David Ning |Antoine Buchard |Charlotte Williams

IntroductionClick to copy section linkSection link copied!Improving polymer sustainability is a very important scientific challenge with recent studies highlighting the combined threats to us all of mismanaged plastic wastes and the ever-growing carbon dioxide emissions across polymer lifecycles.
Rapid Discovery of Celastrol Derivatives as Potent and Selective PRDX1 Inhibitors via Microplate-Based Parallel Compound Library and In Situ Screening

5 days ago | pubs.acs.org | Shuang Chen |Zhenyu Wang |Jia Gao |Yanlin Wang
Formate-Mediated C-C Coupling of Aryl/Vinyl Halides and Triflates: Carbonyl Arylation and Reductive Cross-Coupling

6 days ago | pubs.acs.org | Yu-Hsiang Chang |Yoon Cho |Weijia Shen |Michael J. Krische

Sunday, June 22, 2025 Please be aware that pubs.acs.org is undergoing maintenance starting on Saturday June 21 through Sunday June 22 that may have an impact on your experience. During this time, you may not be able to access certain features like creating a new account, logging in with an existing account, purchasing single articles, saving searches or running existing saved searches, modifying your e-Alert preferences, or accessing Librarian administrative functions.
Divergent Annulations via Organocatalysis: Remote-Controlled and Switchable Reactions of Pyrrolidinone-Based Morita-Baylis-Hillman Carbonates with 2-Arylideneindane-1,3-diones | Organic Letters

1 week ago | pubs.acs.org | Rongzhen Li |Xuling Chen |Pengfei Li
Nonradical Reactions of p-Benzyne Diradicals

1 week ago | pubs.acs.org | Charles Perrin

IntroductionClick to copy section linkSection link copied!This topic was a new area of research for me. I became involved when my colleague, Bill Fenical, a marine natural products chemist at the Scripps Institution of Oceanography, had a question about a natural product, “cyanosporaside”, that he had recently isolated and characterized.
Palladium-Catalyzed Aminocarbonylation Using Nitroarenes under NMP-Mediated Photochemical Conditions

2 weeks ago | pubs.acs.org | Minwoo Park |Karthik Rajan Rajamanickam |Sunwoo Lee

Organic LettersCite this: Org. Lett. 2025, XXXX, XXXClick to copy citationCitation copied!Learn about these metricsArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days. Citations are the number of other articles citing this article, calculated by Crossref and updated daily.
Cocrystal Engineering Using Structural Modularity: Modulating Solid-State Fluorescence through a Stoichio-Morphic Ternary Cocrystal

2 weeks ago | pubs.acs.org | Lavanya Singh |Garima Joshi |Arijit Mukherjee
Lewis Acid-Boosted Nanozyme for In Situ Metallization Electrochemical Sensing of Extracellular Vesicles

2 weeks ago | pubs.acs.org | Xiao Wang |Jing-Yuan Ma |Mingze Lu |Wei Du

Biological and Medical Applications of Materials and InterfacesJune 12, 2025Xiao WangState Key Laboratory of Digital Medical Engineering, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering & Basic Medicine Research and Innovation Center of Ministry of Education, Southeast University, Nanjing 211102, P. R.
Lignin-Based Therapeutics: Targeting Mitochondrial Pathways in Osteosarcoma

2 weeks ago | pubs.acs.org | Yilin Wang |Sheng Zhou |Zaikai Zhuang |Xueying An

Functional Structure/Activity RelationshipsJune 12, 2025 Yilin Wang Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, Nanjing Forestry University, Nanjing 210037, China Sheng Zhou State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School,...