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Jan 14, 2025 | 
nature.com | Lachlan Gilchrist |Thomas P. Spargo |Rebecca Green |David Howard |Jackson G. Thorp |Brett N. Adey | +25 more
AbstractDepression is a risk factor for the later development of Alzheimer’s disease (AD), but evidence for the genetic relationship is mixed. Assessing depression symptom-specific genetic associations may better clarify this relationship.
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Jan 14, 2025 | 
kcl.ac.uk | Cathryn M. Lewis
The world’s largest and most diverse genetic study ever into major depression has revealed nearly 300 previously unknown genetic links to the condition. Published in Cell, the study found that 100 of the newly discovered genetic variations – small differences in the DNA sequence that makes up a gene – were identified due to the inclusion of people of African, East Asian, Hispanic and South Asian descent.
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Dec 19, 2024 | 
kcl.ac.uk | Julian Mutz |Cathryn M. Lewis |Raquel Revuelta Iniesta
Researchers at the Institute of Psychiatry, Psychology & Neuroscience have conducted a comprehensive study to evaluate artificial intelligence based ageing clocks, which predict health and lifespan using data from blood. The researchers trained and tested 17 machine learning algorithms using data on markers in the blood from over 225,000 UK Biobank participants, aged 40 to 69 years when they were recruited.
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Jul 13, 2024 | 
nature.com | Allan Kalungi |Cathryn M. Lewis |Andrew McIntosh |Andrew Mcintosh |Karoline B Kuchenbaecker
AbstractGenetics research has potential to alleviate the burden of mental disorders in low- and middle-income-countries through identification of new mechanistic pathways which can lead to efficacious drugs or new drug targets. However, there is currently limited genetics data from Africa. The Uganda Genome Resource provides opportunity for psychiatric genetics research among underrepresented people from Africa.
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Jun 16, 2024 | 
nature.com | Jacob Bergstedt |Ziyan Ma |Shuyang Yao |Nadine Staples Parker |Oleksandr Frei |Joeri J. Meijsen | +12 more
AbstractMajor depressive disorder (MDD) and cardiovascular disease (CVD) are often comorbid, resulting in excess morbidity and mortality. Here we show that CVDs share most of their genetic risk factors with MDD. Multivariate genome-wide association analysis of shared genetic liability between MDD and atherosclerotic CVD revealed seven loci and distinct patterns of tissue and brain cell-type enrichments, suggesting the involvement of the thalamus.
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Jun 13, 2024 | 
medrxiv.org | Oliver Pain |Ammar Al-Chalabi |Cathryn M. Lewis
OP provides consultancy services for UCB pharma. AAC reports consultancies or advisory boards for Amylyx, Apellis, Biogen, Brainstorm, Cytokinetics, GenieUs, GSK, Lilly, Mitsubishi Tanabe Pharma, Novartis, OrionPharma, Quralis, and Wave Pharmaceuticals. CML sits on the Myriad Neuroscience Scientific Advisory Board and is a Key Opinion Leader for UCB Pharma. OP is supported by a Sir Henry Wellcome Postdoctoral Fellowship [222811/Z/21/Z].
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Jun 3, 2024 | 
kcl.ac.uk | Oliver Pain |Cathryn M. Lewis
The new GenoPred pipeline enables researchers to easily calculate an individual’s likelihood of different health-related outcomes, such as disease and disorders or response to treatment, based on their genetics. Most health-related outcomes are underpinned by thousands of genetic variants. Inherited changes in each gene impacts our risk of different diseases.
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May 1, 2024 | 
medrxiv.org | Mark Adams |Cathryn M. Lewis |Andrew McIntosh |Andrew Mcintosh
AbstractIn a genome-wide association study (GWAS) meta-analysis of 685,808 individuals with major depression (MD) and 4,364,225 controls from 29 countries and across diverse and admixed ancestries, we identify 697 independent associations at 636 loci, 293 of which are novel. Using fine-mapping and functional genomic tools, we find 308 high-confidence gene associations and enrichment of postsynaptic density and receptor clustering.
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Feb 11, 2024 | 
medrxiv.org | Julian Mutz |Raquel Revuelta Iniesta |Cathryn M. Lewis
CML is a member of the scientific advisory board of Myriad Neuroscience, has received speaker fees from SYNLAB and received consultancy fees from UCB. JM and RI declare no financial conflict of interest. This research is funded by the National Institute for Health and Care Research (NIHR) Maudsley Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London.
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Jan 4, 2024 | 
nature.com | Xiangrui Meng |Daniel F Levey |Dora Koller |Mark Adams |Miguel E. Rentería |Dan Stein | +42 more
AbstractMost genome-wide association studies (GWAS) of major depression (MD) have been conducted in samples of European ancestry. Here we report a multi-ancestry GWAS of MD, adding data from 21 cohorts with 88,316 MD cases and 902,757 controls to previously reported data. This analysis used a range of measures to define MD and included samples of African (36% of effective sample size), East Asian (26%) and South Asian (6%) ancestry and Hispanic/Latin American participants (32%).
