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2 months ago | 
nature.com | Qingyang Li |Miao Cao |Dan Stein |Barbara Sahakian |Tianye Jia |Christelle Langley | +22 more
AbstractLaboratory studies show brain maturation involves synaptic pruning and cognitive development. Human studies suggest links between early cognitive performance and later mental health, but inconsistencies remain. It is unclear if specific brain regions mediate this relationship, and the molecular underpinnings are not well understood.
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Jan 8, 2025 | .html&sz=64)
fis.tu-dresden.de | Shi Chen |IMAGEN Consortium |Jia You |Wei Zhang
Abstract Externe IDs Scopus 85181497496 SchlagworteHumans, Genome-Wide Association Study, Hypothalamus/metabolism, Male, Female, Adult, Mental Disorders/genetics, ADAMTS Proteins/genetics, Middle Aged, Mendelian Randomization Analysis
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Jul 14, 2024 | 
nature.com | Runye Shi |Shitong Xiang |Tianye Jia |Trevor Robbins |Jujiao Kang |Tobias Banaschewski | +21 more
AbstractAdolescents exhibit remarkable heterogeneity in the structural architecture of brain development. However, due to limited large-scale longitudinal neuroimaging studies, existing research has largely focused on population averages, and the neurobiological basis underlying individual heterogeneity remains poorly understood.
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Jun 12, 2024 | .html&sz=64)
fis.tu-dresden.de | IMAGEN Consortium
Department of Psychiatry and PsychotherapyUniversidade Federal do Rio Grande do SulCNPqFederal University of São PauloUniversidade Federal do ABCUniversity of TorontoKing's College London (KCL)Université Paris-SaclayUniversity of PennsylvaniaCharité – Universitätsmedizin Berlin Abstract External IDs PubMed 33030612
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Jun 12, 2024 | .html&sz=64)
fis.tu-dresden.de | IMAGEN Consortium
Alcohol misuse is a major public health problem originating from genetic and environmental risk factors. Alterations in the brain epigenome may orchestrate changes in gene expression that lead to alcohol misuse and dependence. Through epigenome-wide association analysis of DNA methylation from human brain tissues, we identified a differentially methylated region, DMR-DLGAP2, associated with alcohol dependence.
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Jun 11, 2024 | .html&sz=64)
fis.tu-dresden.de | IMAGEN Consortium |Juliane H. Fröhner |Michael N. Smolka
University of Amsterdam Universität Heidelberg King's College London (KCL) Trinity College Dublin Universität Mannheim Commissariat à l’énergie atomique et aux énergies alternatives (CEA) University of Vermont Physikalisch-Technische Bundesanstalt École normale supérieure Paris-Saclay Orsay Hospital Universitätsklinikum Schleswig-Holstein Campus Kiel Georg-August-Universität Göttingen Leibniz Institute for Neurobiology Fudan University Charité – Universitätsmedizin Berlin Berliner Institut...
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Oct 19, 2023 | 
nature.com | Tobias Banaschewski |Gareth Barker |Sylvane Desrivières |Herta Flor |Penny Gowland |Andreas Heinz | +17 more
AbstractThe cerebral ventricles are recognized as windows into brain development and disease, yet their genetic architectures, underlying neural mechanisms and utility in maintaining brain health remain elusive. Here we aggregated genetic and neuroimaging data from 61,974 participants (age range, 9 to 98 years) in five cohorts to elucidate the genetic basis of ventricular morphology and examined their overlap with neuropsychiatric traits.
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Sep 22, 2023 | 
nature.com | Feng Chen |Meiyun Wang |Xiaochu Zhang |Wen Qin |Feng Liu |Qiang Xu | +24 more
AbstractExposure to preadult environmental exposures may have long-lasting effects on mental health by affecting the maturation of the brain and personality, two traits that interact throughout the developmental process. However, environment-brain-personality covariation patterns and their mediation relationships remain unclear.
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Aug 21, 2023 | 
nature.com | Seyed Mostafa Kia |Sebastian Siehl |Sylvane Desrivières |Herta Flor |Penny Gowland |Andreas Heinz | +13 more
AbstractEnvironmental adversities constitute potent risk factors for psychiatric disorders. Evidence suggests the brain adapts to adversity, possibly in an adversity-type and region-specific manner. However, the long-term effects of adversity on brain structure and the association of individual neurobiological heterogeneity with behavior have yet to be elucidated.
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Aug 15, 2023 | 
nature.com | Shitong Xiang |Tianye Jia |Tobias Banaschewski |Gareth Barker |Christian Büchel |Sylvane Desrivières | +15 more
AbstractSmoking of cigarettes among young adolescents is a pressing public health issue. However, the neural mechanisms underlying smoking initiation and sustenance during adolescence, especially the potential causal interactions between altered brain development and smoking behaviour, remain elusive.
