Mikael Landén

Nov 4, 2024 | nature.com | Christoph Abe |Francesco Benedetti |Erlend Bøen |Katharina Brosch |Erick J. Canales-Rodriguez |Torbjørn Elvsåshagen | +34 more

AbstractAlthough specific risk factors for brain alterations in bipolar disorders (BD) are currently unknown, obesity impacts the brain and is highly prevalent in BD. Gray matter correlates of obesity in BD have been well documented, but we know much less about brain white matter abnormalities in people who have both obesity and BD.

Aug 28, 2024 | nature.com | Jiantao Chen |Zhijian Yang |Ranran Zhai |Xiao Feng |Ting Li |Denis Maslov | +25 more

AbstractUnderstanding the genetic basis of neuro-related proteins is essential for dissecting the molecular basis of human behavioural traits and the disease aetiology of neuropsychiatric disorders. Here the SCALLOP Consortium conducted a genome-wide association meta-analysis of over 12,000 individuals for 184 neuro-related proteins in human plasma. The analysis identified 125 cis-regulatory protein quantitative trait loci (cis-pQTL) and 164 trans-pQTL.

Mar 3, 2024 | onlinelibrary.wiley.com | Mikael Landén

Mikael Landén Puberty stands as a pivotal milestone in human development. Marking the transition from childhood to adolescence and beyond involves a complex interplay of biological, psychological and social changes. Puberty can be halted using gonadotropin-releasing hormone agonists (GnRHa) commonly referred to as ‘puberty blockers’.

Jan 31, 2024 | jamanetwork.com | Suvi M Virtanen |Mikael Landén |Sahlgrenska Academy

Antidepressant Use and Manic Episodes in Children and Adolescents With Unipolar Depression—Reply In Reply The letter by Boström et al questions the external validity of our study1 based on concerns regarding antidepressant dosing, regional variation in the prevalence of bipolar disorder, and the prevalence of bipolar disorder diagnoses in adolescent boys. We appreciate the comments and think they highlighted a few important features of studies using real-world data.

Sep 28, 2023 | nature.com | Robert Karlsson |Jie Song |Kaarina Kowalec |Christian Rück |Caitlin Clements |Cathryn M. Lewis | +1 more

AbstractTreatment response and resistance in major depressive disorder (MDD) are suggested to be heritable. Due to significant challenges in defining treatment-related phenotypes, our understanding of their genetic bases is limited. This study aimed to derive a stringent definition of treatment resistance and to investigate the genetic overlap between treatment response and resistance in MDD.