P. Eline Slagboom

Nov 11, 2024 | analyticalsciencejournals.onlinelibrary.wiley.com | Bingshu He |Rawi Ramautar |Marian Beekman |P. Eline Slagboom

AA arachidonic acid BHT butylated hydroxytoluene BuOH 1-butanol EMA European Medicines Agency EPA eicosapentaenoic acid ISTD internal standard LLE liquid–liquid extraction MeOH methanol MTBE methyl tert-butyl ether PGs prostaglandins PUFAs polyunsaturated fatty acids QC quality control SRM selected reaction monitoring 1 Introduction Oxylipins are a group of signaling lipids derived from polyunsaturated fatty acids (PUFAs) through enzymatic or non-enzymatic oxidation processes. Non-esterified...

Sep 15, 2024 | nature.com | Jesse R. Poganik |Daniel Belsky |Joe LaCroix |Alan Cohen |Steven R. Cummings |Luigi Ferrucci | +15 more

AbstractBiomarkers of aging (BOA) are quantitative parameters that predict biological age and ideally its changes in response to interventions. In recent years, many promising molecular and omic BOA have emerged with an enormous potential for translational geroscience and improving healthspan. However, clinical translation remains limited, in part due to the gap between preclinical research and the application of BOA in clinical research and other translational settings.

Jul 24, 2024 | medrxiv.org | Mar Rodriguez-Girondo |P. Eline Slagboom |Marian Beekman |Kerstin Alexandra Schorr

The authors have declared no competing interest. P.E. Slagboom, M. Beekman, and L.C.P.G.M de Groot have received funding from the Vitality Oriented Innovations for the Lifecourse of the Ageing Society (VOILA) Consortium [ZonMw 457001001]. All authors declare no conflict of interest. I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.

Jul 5, 2024 | rbmojournal.com | P. Eline Slagboom |Marian Beekman |Femke Roelofs |Frank J.M. Broekmans

Mar 6, 2024 | nature.com | Minna K. Karjalainen |Eeva Sliz |Elias Allara |Weihua Zhang |Pekka Jousilahti |Kati Kristiansson | +46 more

AbstractGenome-wide association analyses using high-throughput metabolomics platforms have led to novel insights into the biology of human metabolism1,2,3,4,5,6,7. This detailed knowledge of the genetic determinants of systemic metabolism has been pivotal for uncovering how genetic pathways influence biological mechanisms and complex diseases8,9,10,11.