PLOS Medicine

PLOS Medicine, which was initially known as PLoS Medicine, is a weekly medical journal that is peer-reviewed and covers a wide range of topics within the medical field. It was launched on October 19, 2004, as the second journal from the Public Library of Science (PLOS), a non-profit organization dedicated to open access publishing. All articles in PLOS Medicine are available under the Creative Commons "by-attribution" license. To support the journal financially, authors are generally required to pay fees for publication. Initially available in both online and print formats until 2005, the journal now exists solely in an online format. Larry Peiperl has been the chief editor since 2013, taking over from Virginia Barbour, the previous editor.

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Articles

Comprehensive scoping review on adherence to 24-hour movement guidelines and socioeconomic indicators in children and adolescents

1 week ago | journals.plos.org | Letícia Gonçalves |Santa Catarina |Suellem Zanlorenci |Jérémy Vanhelst

Loading metrics Open Access Peer-reviewedResearch Article Citation: Gonçalves L, Zanlorenci S, Da Silva Almeida MF, Vanhelst J, Santos Silva DA (2025) Comprehensive scoping review on adherence to 24-hour movement guidelines and socioeconomic indicators in children and adolescents. PLoS ONE 20(4): e0321103.
Breaking the climate silence: Predictors of discussing global warming with family and friends

1 week ago | journals.plos.org | Margaret Orr |Amanda Borth |John E. Kotcher |Eryn Campbell

Citation: Orr M, Borth A, Kotcher J, Campbell E, Myers T, Maibach E, et al. (2025) Breaking the climate silence: Predictors of discussing global warming with family and friends. PLOS Clim 4(4): e0000538. https://doi.org/10.1371/journal.pclm.0000538Editor: Terence Epule Epule, UQAT: Universite du Quebec en Abitibi Temiscamingue, CANADAReceived: August 19, 2024; Accepted: February 17, 2025; Published: April 17, 2025Copyright: © 2025 Orr et al.
Evaluation of protein intake and protein quality in New Zealand vegans

1 week ago | journals.plos.org | Matthieu Vignes |Nick Smith |Warren McNabb

Loading metrics Open Access Peer-reviewedResearch Article Citation: Soh BXP, Vignes M, Smith NW, von Hurst PR, McNabb WC (2025) Evaluation of protein intake and protein quality in New Zealand vegans. PLoS ONE 20(4): e0314889. https://doi.org/10.1371/journal.pone.0314889Editor: Ewa Tomaszewska, University of Life Sciences in Lublin, POLANDReceived: November 24, 2024; Accepted: February 26, 2025; Published: April 16, 2025Copyright: © 2025 Soh et al.
First-trimester exposure to macrolides and risk of major congenital malformations compared with amoxicillin: A French nationwide cohort study

1 week ago | journals.plos.org | Anh Tran |Mahmoud Zureik |Jeanne Sibiude

Loading metrics Open Access Peer-reviewedResearch Article ? This is an uncorrected proof. Citation: Tran A, Zureik M, Sibiude J, Miranda S, Drouin J, Marty L, et al. (2025) First-trimester exposure to macrolides and risk of major congenital malformations compared with amoxicillin: A French nationwide cohort study. PLoS Med 22(4): e1004576.
A novel gastric ulcer model in rats using filter paper with acetic acid

1 week ago | journals.plos.org | Siyuan Dong |Xi’an Jiaotong |Shaanxi province |Xudong WANG

Loading metrics Open Access Peer-reviewedResearch Article Citation: Dong S, Wang X, Liu Y, Qiao L, Xue Q, Zhou Y, et al. (2025) A novel gastric ulcer model in rats using filter paper with acetic acid. PLoS ONE 20(4): e0319096. https://doi.org/10.1371/journal.pone.0319096Editor: Sairah Hafeez Kamran, Lahore College for Women University, PAKISTANReceived: June 27, 2024; Accepted: January 27, 2025; Published: April 15, 2025Copyright: © 2025 Dong et al.
N6-methyladenosine modification of the subgroup J avian leukosis viral RNAs attenuates host innate immunity via MDA5 signaling

2 weeks ago | journals.plos.org | Mengmeng Yu |Li Zhang |Ying Wang |Suyan Wang |PLOS Pathogens

Loading metrics Open Access Peer-reviewedResearch Article ? This is an uncorrected proof. Citation: Yu M, Zhang L, Wang Y, Wang S, Liu Y, Liu P, et al. (2025) N6-methyladenosine modification of the subgroup J avian leukosis viral RNAs attenuates host innate immunity via MDA5 signaling. PLoS Pathog 21(4): e1013064. https://doi.org/10.1371/journal.ppat.1013064Editor: Richard A.
Physical activity and diet pattern do not mitigate C-reactive protein increases associated with oral contraceptive use

2 weeks ago | journals.plos.org | Eric T Trexler |David Eagle |Herman Pontzer

Loading metrics Open Access Peer-reviewedResearch Article Citation: Trexler ET, Eagle DE, Pontzer H (2025) Physical activity and diet pattern do not mitigate C-reactive protein increases associated with oral contraceptive use. PLoS ONE 20(4): e0319928. https://doi.org/10.1371/journal.pone.0319928Editor: Samiullah Khan, The University of Lahore, PakistanReceived: May 10, 2024; Accepted: February 10, 2025; Published: April 8, 2025Copyright: © 2025 Trexler et al.
Correction: Best-worst scaling preferences among patients with well-controlled epilepsy: Pilot results

3 weeks ago | journals.plos.org | Samuel W. Terman |Hélène E. Aschmann |David Hutton |James Burke

In the Funding statement, the grant number from the funder Early Postdoc.Mobility Fellowship by the Swiss National Science Foundation is not indicated. The grant number is: 191414. Reference1. Terman SW, Aschmann HE, Hutton DW, Burke JF. Best-worst scaling preferences among patients with well-controlled epilepsy: Pilot results. PLoS One. 2023;18(3): e0282658.
The look of a leader

3 weeks ago | journals.plos.org | Katherine Sun |Michael L. Slepian |Modupe Akinola

Loading metrics Open Access Peer-reviewedResearch Article Citation: Sun KQ, Slepian ML, Akinola M (2025) The look of a leader. PLoS ONE 20(4): e0320836. https://doi.org/10.1371/journal.pone.0320836Editor: Megan Louise Willis, Australian Catholic University, AUSTRALIAReceived: November 14, 2023; Accepted: February 20, 2025; Published: April 3, 2025Copyright: © 2025 Sun et al.
Comorbidities and health-related quality of life among rural older community-dwellers in Vietnam

3 weeks ago | journals.plos.org | Hai Vu |Thai Binh |Hao Tang |Nam Dinh

The team collecting data included researchers and medical students from Thai Binh University of Medicine and Pharmacy, as well as health workers from four community health centers. All data collectors underwent intensive training sessions conducted by field specialists to develop strong interview and communication abilities. The participants were familiarized with the purpose and characteristics of the questionnaire to ensure their comprehension and active participation in the study.