PLOS Medicine

PLOS Medicine, which was initially known as PLoS Medicine, is a weekly medical journal that is peer-reviewed and covers a wide range of topics within the medical field. It was launched on October 19, 2004, as the second journal from the Public Library of Science (PLOS), a non-profit organization dedicated to open access publishing. All articles in PLOS Medicine are available under the Creative Commons "by-attribution" license. To support the journal financially, authors are generally required to pay fees for publication. Initially available in both online and print formats until 2005, the journal now exists solely in an online format. Larry Peiperl has been the chief editor since 2013, taking over from Virginia Barbour, the previous editor.

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Articles

Role of the CTCF binding site in Human T-Cell Leukemia Virus-1 pathogenesis

5 days ago | journals.plos.org | Ancy Joseph |Xiaogang Cheng |John Harding |Jacob Al-Saleem |PLOS Pathogens

Loading metrics Open Access Peer-reviewedResearch Article ? This is an uncorrected proof. Citation: Joseph A, Cheng X, Harding J, Al-Saleem J, Green P, Griffith M, et al. (2025) Role of the CTCF binding site in Human T-Cell Leukemia Virus-1 pathogenesis. PLoS Pathog 21(6): e1012293. https://doi.org/10.1371/journal.ppat.1012293Editor: Charles R M.
Comparative repeatome analysis of Pyrgomorphidae and Acrididae (Orthoptera: Caelifera) revealed the contribution of repetitive DNA in genome gigantism

5 days ago | journals.plos.org | Muhammad Salman |Shaanxi Normal |Xuanzeng Liu |Nian Liu

Loading metrics Open Access Peer-reviewedResearch Article Citation: Salman M, Liu X, Liu N, Huang Y (2025) Comparative repeatome analysis of Pyrgomorphidae and Acrididae (Orthoptera: Caelifera) revealed the contribution of repetitive DNA in genome gigantism. PLoS One 20(6): e0325165.
Analysis of the impact of different landing heights and lateralities on lower limb joint load based on statistical parametric mapping

1 week ago | journals.plos.org | Lian Duan |Yuan Gao |Feng Gao |Yang Sun

Loading metrics Open Access Peer-reviewedResearch Article Citation: Duan L, Gao Y, Gao F, Sun Y, Tian N (2025) Analysis of the impact of different landing heights and lateralities on lower limb joint load based on statistical parametric mapping. PLoS One 20(5): e0324656.
Examining the impact of maternal experiences of domestic violence on the mental health of their adolescent children in India

1 week ago | journals.plos.org | Amritha Gourisankar |Preethi Ravi |Ameeta S. Kalokhe |Rachel Hall

Loading metrics Open Access Peer-reviewedResearch Article Citation: Gourisankar A, Ravi P, Kalokhe A, Waford Hall R, Vaidya N, Sharma E, et al. (2025) Examining the impact of maternal experiences of domestic violence on the mental health of their adolescent children in India. PLoS One 20(5): e0304936.
Correction: How to choose the intraocular lens power calculation formulas in eyes with extremely long axial length? A systematic review and meta-analysis

2 weeks ago | journals.plos.org | Xiaoyu Li |Xiaodong Wang

In the Funding statement, the grant number from the funder Project of the National Natural Science Foundation of Sichuan Provincial Department of Science and Technology is listed incorrectly. The correct grant number is: 2023NSFSC0595. Reference1. Li X, Wang X, Liao X. How to choose the intraocular lens power calculation formulas in eyes with extremely long axial length? A systematic review and meta-analysis. PLoS One. 2024;19(1):e0296771.
Horizontal gene transfer of molecular weapons can reshape bacterial competition

2 weeks ago | journals.plos.org | Elisa T. Granato |Jacob Palmer |Christian Kirk |Connor Sharp

Loading metrics Open Access Peer-reviewedResearch Article Citation: Granato ET, Palmer JD, Kirk C, Sharp C, Shillcock G, Foster KR (2025) Horizontal gene transfer of molecular weapons can reshape bacterial competition. PLoS Biol 23(5): e3003095. https://doi.org/10.1371/journal.pbio.3003095Academic Editor: Sam Paul Brown, Georgia Institute of Technology, UNITED STATES OF AMERICAReceived: August 29, 2024; Accepted: March 4, 2025; Published: May 21, 2025Copyright: © 2025 Granato et al.
Correction: Sustainable visions: Unsupervised machine learning insights on global development goals

3 weeks ago | journals.plos.org | Alberto García-Rodríguez |Matias Nunez |Miguel Perez |Miguel Pérez |Tzipe Govezensky

There are errors in the Author Contributions. The correct contributions are,Conceptualization: Alberto García-Rodríguez, Matias Núñez, Rafael A. Barrio, Carlos Gershenson, Kimmo K.
RNA degradation patterns in cardiac tissues kept at different time intervals and temperatures before RNA sequencing

3 weeks ago | journals.plos.org | Stine Jacobsen |Jacob Tfelt-Hansen |Morten Holdgaard Smerup |Niels Morling

Loading metrics Open Access Peer-reviewedResearch Article Citation: Jacobsen SB, Tfelt-Hansen J, Smerup MH, Morling N, Andersen JD (2025) RNA degradation patterns in cardiac tissues kept at different time intervals and temperatures before RNA sequencing. PLoS One 20(5): e0323786. https://doi.org/10.1371/journal.pone.0323786Editor: Francesco Sessa, University of Catania, ITALYReceived: October 17, 2024; Accepted: April 15, 2025; Published: May 15, 2025Copyright: © 2025 Jacobsen et al.
The comparative effectiveness and safety of fluticasone-salmeterol via metered-dose versus dry powder inhalers for COPD: A new user cohort study

3 weeks ago | journals.plos.org | Kevin Rader |Shirley Wang |Aaron S. Kesselheim |Brandon J. Demkowicz

Loading metrics Open Access Peer-reviewedResearch Article Citation: Demkowicz BJ, Rader K, Wang SV, Kesselheim AS, Feldman WB (2025) The comparative effectiveness and safety of fluticasone-salmeterol via metered-dose versus dry powder inhalers for COPD: A new user cohort study. PLoS Med 22(5): e1004596. https://doi.org/10.1371/journal.pmed.1004596Academic Editor: Alexander G.
Molecular states underlying neuronal cell type development and plasticity in the postnatal whisker cortex

3 weeks ago | journals.plos.org | Salwan Butrus |Christopher Yoo |Daniel Feldman

Loading metrics Open Access Peer-reviewedResearch Article ? This is an uncorrected proof. Citation: Butrus S, Monday HR, Yoo CJ, Feldman DE, Shekhar K (2025) Molecular states underlying neuronal cell type development and plasticity in the postnatal whisker cortex. PLoS Biol 23(5): e3003176.