PLOS Medicine

PLOS Medicine, which was initially known as PLoS Medicine, is a weekly medical journal that is peer-reviewed and covers a wide range of topics within the medical field. It was launched on October 19, 2004, as the second journal from the Public Library of Science (PLOS), a non-profit organization dedicated to open access publishing. All articles in PLOS Medicine are available under the Creative Commons "by-attribution" license. To support the journal financially, authors are generally required to pay fees for publication. Initially available in both online and print formats until 2005, the journal now exists solely in an online format. Larry Peiperl has been the chief editor since 2013, taking over from Virginia Barbour, the previous editor.

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Articles

Uncovering common disease mechanisms and critical biomarkers in Crohn’s disease with concurrent psoriasis and exploring potential therapeutic agents

1 week ago | journals.plos.org | Tianqi Liu |Liaoning Province |Xiaoqing Zhang |Ruiqi Chen

Loading metrics Open Access Peer-reviewedResearch Article Citation: Liu T, Zhang X, Chen R, Sun Y, Zhang R, Zhang L, et al. (2025) Uncovering common disease mechanisms and critical biomarkers in Crohn’s disease with concurrent psoriasis and exploring potential therapeutic agents. PLoS One 20(6): e0324007.
Correction: Close to the border-Resilience in healthcare in a European border region: Findings of a needs analysis

1 week ago | journals.plos.org | Sophie Lambert |Lea Bouché |Martin Klasen |Saša Sopka

COMPAS Consortium should not have been included in the author byline. Reference1. Loeffler LAK, Lambert SI, Bouché L, Klasen M, Sopka S, Vogt L, et al. Close to the border-Resilience in healthcare in a European border region: Findings of a needs analysis. PLoS One. 2025;20(1):e0316105.
Suicidal ideation and non-fatal suicidal self-directed violence prevalence and associations among Veterans residing in U.S. Pacific Island Territories: Guam, American Samoa, and the Northern Mariana Islands

1 week ago | journals.plos.org | Lindsey L. Monteith |Julie A. Kittel |Ryan Holliday |Alexandra Schneider

Citation: Monteith LL, Kittel JA, Holliday R, Schneider AL, Herring-Nathan E, Krishnamurti LS, et al. (2025) Suicidal ideation and non-fatal suicidal self-directed violence prevalence and associations among Veterans residing in U.S. Pacific Island Territories: Guam, American Samoa, and the Northern Mariana Islands. PLoS One 20(6): e0326533.
Aspirations to study medicine, perceptions of a good doctor, and their influence on specialty choice among medical students

1 week ago | journals.plos.org | Quang Nguyen |Hoang Nguyen |Hoàng Nguyên |Hoàng Nguyễn |Minh Ngo |Son Nguyen

Citation: Nguyen QT, Luong TTH, Nguyen HV, Ngo MQ, Nguyen SH, Nguyen NLK (2025) Aspirations to study medicine, perceptions of a good doctor, and their influence on specialty choice among medical students. PLoS One 20(6): e0326266. https://doi.org/10.1371/journal.pone.0326266Editor: Muhammad Haroon Stanikzai, Kandahar University, Faculty of Medicine, AFGHANISTANReceived: February 28, 2025; Accepted: May 27, 2025; Published: June 17, 2025Copyright: © 2025 Nguyen et al.
Protease-mediated activation of Par2 elicits calcium waves during zebrafish egg activation and blastomere cleavage

1 week ago | journals.plos.org | Jiajia Ma |Nanyang Technological |Tom Carney

Loading metrics Open Access Peer-reviewedResearch Article Citation: Ma J, Carney TJ (2025) Protease-mediated activation of Par2 elicits calcium waves during zebrafish egg activation and blastomere cleavage. PLoS Biol 23(6): e3003181. https://doi.org/10.1371/journal.pbio.3003181Academic Editor: Carmen J.
Proteostasis signatures in human diseases

1 week ago | journals.plos.org | Christine Lim |Michele Vendruscolo

Fig 7. Central role of mid-stage regulatory proteins in the proteostasis network perturbations in AD. The functional interaction network of AD-associated proteostasis network genes (from all disease stages) are shown. Genes affected in the early stage are depicted as blue nodes; mid stage as beige nodes; and late stage as red nodes.
Secure energy outage analysis of UAV swarm-based network

1 week ago | journals.plos.org | Tien Nguyen |Hoang Tran

Citation: Nguyen TH, Tran HV (2025) Secure energy outage analysis of UAV swarm-based network. PLoS One 20(6): e0325785. https://doi.org/10.1371/journal.pone.0325785Editor: Daosen Zhai, Northwestern Polytechnical University, CHINAReceived: March 2, 2025; Accepted: May 18, 2025; Published: June 13, 2025Copyright: © 2025 Nguyen, Tran.
The impact of the COVID-19 pandemic on vaccinations in United States primary care practices

2 weeks ago | journals.plos.org | Omer Atac |Istanbul Medipol |Lars Peterson |Teresa M. Waters

DiscussionReceipt of non-COVID-19 vaccines through primary care declined significantly during the pandemic. These declines were consistent across age groups—children, adolescents, and adults—and persisted over time. This pattern aligns with prior studies showing substantial disruptions in routine immunizations during the early stages of the COVID-19 pandemic, as in-person care was postponed or avoided [6–9].
Prediction of electrical load demand using combined LHS with ANFIS

2 weeks ago | journals.plos.org | Ahmed Ismail |Electrical Power |Al Azhar |Hassan Mohamed

Loading metrics Open Access Peer-reviewedResearch Article Citation: Ismail AG, Elbanna SHA, Mohamed HS (2025) Prediction of electrical load demand using combined LHS with ANFIS. PLoS One 20(6): e0325747. https://doi.org/10.1371/journal.pone.0325747Editor: Tien Anh Tran, Vietnam Maritime University, VIET NAMReceived: July 2, 2024; Accepted: May 16, 2025; Published: June 10, 2025Copyright: © 2025 Ismail et al.
Sensorimotor integration enhances temperature stimulus processing

2 weeks ago | journals.plos.org | Lindsay Anderson |Jamie D Costabile |Sina Schwinn |Delia Calderon

Loading metrics Open Access Peer-reviewedResearch Article Citation: Anderson LS, Costabile JD, Schwinn S, Calderon D, Haesemeyer M (2025) Sensorimotor integration enhances temperature stimulus processing. PLoS Comput Biol 21(6): e1013134. https://doi.org/10.1371/journal.pcbi.1013134Editor: Matthieu Louis, University of California Santa Barbara, UNITED STATES OF AMERICAReceived: November 5, 2024; Accepted: May 13, 2025; Published: June 10, 2025Copyright: © 2025 Anderson et al.