Cell Press

1 week ago | cell.com | Jonathan Pekar |Spyros Lytras |Mahan Ghafari |Andrew Magee |Edyth Parker |Yu Wang | +13 more

Keywords molecular epidemiology sarbecoviruses virus evolution phylogeography Introduction Horseshoe bats (Rhinolophus spp.) are the main hosts of the Sarbecovirus subgenus1 (genus Betacoronavirus, family Coronaviridae) and, likely via virus transmission through transient intermediate species, were the source of SARS-CoV (referred to hereafter as SARS-CoV-1, now extinct) and SARS-CoV-2.2,3,4 Since the first emergence of SARS-CoV-1 in Guangzhou, Guangdong Province, in 2002 and SARS-CoV-2...

2 weeks ago | cell.com | Stephanie E Sansbury |Yevgeniy V. Serebrenik |Tomer Lapidot |David SMith |David Smith |George M. Burslem | +1 more

Keywordspooled taggingproteostasisin situ sequencingprotein misfoldingprotein localizationhydrophobic targetingIntroductionLarge-scale multiplexed imaging and gene perturbation technologies have transformed mammalian cell biology but are predominantly limited to nucleic acids. This is due to the ease of generating specific targeting reagents via sequence complementarity, which does not extend to the proteins.

3 weeks ago | cell.com | Kami Pekayvaz |Badr Kilani |Markus Joppich |Luke Eivers |Sophia Brambs |Viktoria Knottenberg | +31 more

Keywords immunothrombosis thrombosis immune landscape neutrophils monocytes innate immunity single-cell multi-omics immunothrombolysis thrombus resolution immunothrombotic dysregulation thromboinflammation stroke immune-cell plasticity organ ischemia Introduction Thrombosis and thromboembolism are a major global cause of morbidity and mortality by leading to myocardial infarction, stroke, and venous thromboembolism.1,2 Simultaneously, anti-thrombotic therapies carry a relevant risk of...

3 weeks ago | cell.com | Sung Min Son |Farah Siddiqi |Ana Lopez |Ana López |Rizwan Ansari |Sylwia D. Tyrkalska | +4 more

ArticleOnline nowOpen access 1Cambridge Institute for Medical Research (CIMR), University of Cambridge, Cambridge, UK 2UK Dementia Research Institute, Cambridge Institute for Medical Research (CIMR), University of Cambridge, Cambridge, UK 3Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK 4UK Dementia Research Institute, Department of Clinical Neurosciences, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK 5Centre for...

4 weeks ago | cell.com | Dario Tommasini |Takeshi Yoshimatsu |Teresa Puthussery |Tom Baden |Karthik Shekhar

1Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA 2Department of Ophthalmology and Visual Sciences, Washington University in St. Louis School of Medicine, St. Louis, MO 63110, USA 3Vision Sciences Graduate Group, University of California, Berkeley, Berkeley, CA 94720, USA 4Herbert Wertheim School of Optometry and Vision Science, University of California, Berkeley, Berkeley, CA 94720, USA 5Center for Sensory Neuroscience and Computation, Sussex...