Cancer

Cancer is a global journal created by the American Cancer Society that features original articles and invited content focused on significant clinical research advancements. Each edition aims to cover a wide range of topics within oncology, ensuring that it offers valuable insights for everyone engaged in cancer research, prevention, treatment, and patient support.

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English

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Articles

The hidden costs of clinical trials

3 weeks ago | acsjournals.onlinelibrary.wiley.com | Bryn Nelson |William C. Faquin

Amid the intense controversy over drastic cuts to the National Institutes of Health (NIH) and its workforce, a hotly contested cap on the NIH’s reimbursement of indirect costs for facilities and administrative expenses is focusing new attention on the financial burden of the institutions and trial participants that make clinical research possible.
Circulating tumor DNA dynamic variation predicts sotorasib efficacy in KRASp.G12C‐mutated advanced non‐small cell lung cancer

4 weeks ago | acsjournals.onlinelibrary.wiley.com | Francesco Passiglia |Francesco Pepe |Gianluca Russo |Edoardo Garbo

INTRODUCTION Recently, an exon 2 p.G12C Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) mutation was introduced in the arena of positive predictive biomarkers to be tested for treatment selection in patients with metastatic non-small cell lung cancer (NSCLC).1 Sotorasib is the first-in-class covalent off inhibitor, able to irreversibly lock the KRAS G12C–mutated protein in its inactive state, impairing the downstream oncogenic signaling pathways.2, 3 Based on the positive results from the...
Chronic opioid use and incident opioid use disorders in survivors of adolescent and young adult cancer after cancer treatment

1 month ago | acsjournals.onlinelibrary.wiley.com | Chun Chao |Hui Zhou |Dov Shalman |Katherine Pak

DATA AVAILABILITY STATEMENT Anonymized data that support the findings of this study may be made available from the corresponding author on reasonable request from qualified researchers with documented evidence of training for human subjects protections.
Repurposed drugs may lend a new hand as add‐ons to existing cancer treatments

1 month ago | acsjournals.onlinelibrary.wiley.com | Bryn Nelson |William C. Faquin

Despite the inroads made in improving treatments for a wide range of cancers, researchers are coming to grips with the unsettling realization that malignant cells still have a surprising number of escape routes. Block one, and another seems to open up.
Top advances of the year: Neoadjuvant immunotherapy in melanoma

1 month ago | acsjournals.onlinelibrary.wiley.com | Monica Chen |Michael A. Postow

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Reply to “Reevaluating the impact of physical inactivity on cancer risk: Methodological limitations and considerations”

2 months ago | acsjournals.onlinelibrary.wiley.com | Brigid Lynch |Julie Bassett |Roger Milne |Alpa Patel

Corresponding Author Brigid M. Lynch PhD Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia Physical Activity Laboratory, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia Correspondence Brigid M. Lynch, Cancer Epidemiology Division, Cancer Council Victoria, Level 8, 200 Victoria Parade East, Melbourne 3002, Victoria, Australia.
Gender equity gap persists, addressing the root cause through the lens of gynecologic oncology: An evidenced‐based review

2 months ago | acsjournals.onlinelibrary.wiley.com | Jasmine A Ebott |Kelsea R. Grant |John Farley |Marina Stasenko

CONFLICT OF INTEREST STATEMENT Marina Stasenko received compensation for participation on Healthcare Disparities in Endometrial Cancer Advisory Board in July 2024, sponsored by GSK. The other authros declare no conflicts of interest. REFERENCES 1, , , , , . The gender authorship gap in gynecologic oncology research. Gynecol Oncol Rep. 2019; 29: 83-84. doi:10.1016/j.gore.2019.07.011 2, , , et al. Take me to your leader: reporting structures and equity in academic gynecologic oncology.
Cytology‐Radiology Correlation Series: Pancreatic cytopathology

2 months ago | acsjournals.onlinelibrary.wiley.com | Judy A. Trieu |Andrew Gilman |Katerina Konstantinoff |Maria Lozano

INTRODUCTION Pancreatic lesions are rising in prevalence, likely because of increasing access to cross-sectional imaging. They can be subtyped into neoplastic and non-neoplastic lesions. Some lesions are characteristic on computed tomography (CT), magnetic resonance imaging (MRI), and/or endoscopic ultrasound (EUS), whereas others are nonspecific.
Natural trajectory subclasses of cognitive impairment in breast cancer patients experiencing insomnia

2 months ago | acsjournals.onlinelibrary.wiley.com | Oxana Palesh |Sarah Braun |Tina Truong |Susan Hong

INTRODUCTION Cancer-related cognitive impairment (CRCI) is a very common adverse effect of cancer and its therapies.1 Cancer itself may negatively impact cognition via vascular and immunological pathways.
A second look at the status quo for secondary acute myeloid leukemia after hypomethylating agents

2 months ago | acsjournals.onlinelibrary.wiley.com | Daniel Peters |Joshua F. Zeidner

CONFLICT OF INTEREST STATEMENT Joshua F. Zeidner reports consulting or advisory roles for AbbVie, AstraZeneca, Daiichi Sankyo, Foghorn, Genmab, Gilead, Neogenomics, Novartis, Sellas, Servier, Shattuck Labs, Sumitomo Pharma, and Syndax; and research funding from AbbVie, Akesobio, Arog, AstraZeneca, Faron, Gilead, Jazz, Loxo, Merck, Newave, Novartis, Sellas, Shattuck Labs, Stemline, Sumitomo Pharma, and Zentalis. The other author declares no conflicts of interest.