Nature Reviews Drug Discovery

Nature Reviews Drug Discovery is a monthly publication designed for professionals involved in drug discovery and development. Each issue features top-notch reviews and insights on a wide range of topics. Additionally, it includes news articles that explore current trends in drug discovery, brief summaries of important research papers, and quick updates on recent developments like new drug approvals, patent issues, and evolving industry strategies.

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Harvard vs Trump: what this epic battle means for science

2 days ago | nature.com | Jeff Tollefson

Mary Rice was among hundreds of scientists at Harvard University who watched helplessly as millions of dollars in research funds disappeared in an instant in mid-May. Two of the pulmonologist’s grants were formally cancelled as part of a series of punitive actions taken by the administration of US President Donald Trump against the university. Little justification was given to Rice aside from a statement that her research does not align with government priorities.
Enhancing CAR-T cell efficacy through IFN ablation

2 days ago | nature.com | M. Teresa Villanueva

Chimeric antigen receptor (CAR)-T cells have revolutionized the treatment of haematological malignancies. However, challenges — such as relapse owing to insufficient persistence of CAR-T cells — remain. Now, writing in Science Translational Medicine, Bailey et al. have demonstrated that knocking out the interferon-gamma (IFN-γ) receptor (IFN-γR) in CAR-T cells enhances their efficacy and persistence in models of haematological and solid tumours.
Is AI watching you? The hidden links between research and surveillance

3 days ago | nature.com | Benjamin Thompson |Shamini Bundell

Download the Nature Podcast 25 June 2025We’d like to learn more about our listeners, please help us out by filling in this short survey. In this episode:00:45 Is AI-research being co-opted to keep track of people? A significant amount of research in the AI field of computer vision is being used to analyse humans in ways that support the development of surveillance technologies, according to new research.
A sweet summer of science - Nature Methods

3 days ago | nature.com | Vivien Marx

Some graduate students, postdoctoral fellows and senior researchers choose a special kind of science-focused summer.
Molecular mechanism of pH sensing and activation in GPR4 reveals proton-mediated GPCR signaling - Cell Discovery

4 days ago | nature.com | Chongzhao You |Shimeng Guo |Tianwei Zhang |Xinheng He |Youwei Xu |Yi Jiang | +1 more

AbstractMaintaining pH homeostasis is critical for cellular function across all living organisms. Proton-sensing G protein-coupled receptors (GPCRs), particularly GPR4, play a pivotal role in cellular responses to pH changes. Yet, the molecular mechanisms underlying their proton sensing and activation remain incompletely understood. Here we present high-resolution cryo-electron microscopy structures of GPR4 in complex with G proteins under physiological and acidic pH conditions.
How to spy on condensates - Nature Methods

4 days ago | nature.com | Vivien Marx

Scientists track how these membraneless biomolecular foci self-organize for their cellular tasks. You have full access to this article via your institution. Condensates are diverse membraneless organelles in eukaryotic cells. Fluorescently tagged components of nucleolar condensates are seen here in Xenopus eggs. Condensates in a eukaryotic cell’s cytoplasm or nucleus are imbued with otherness1,2,3.
Comparison of induction with arsenic trioxide or chemotherapy in a real-world cohort of patients with high-risk acute promyelocytic leukemia - Leukemia

4 days ago | nature.com | Delphine Lebon |Nicolas Duployez |Christophe Willekens |Thomas Cluzeau |Christian Récher |Mathilde Hunault-Berger | +1 more

AbstractFront-line treatment with all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) is superior to standard ATRA and chemotherapy (CHT) in patients with low-/intermediate-risk acute promyelocytic leukemia (APL). However, for high-risk (HR) patients (defined as those with a white blood cell count ≥ 10×10⁹/L), the role of ATRA-ATO is subject to debate, and study data are scarce.
The changing landscape of cannabis use: impact on maternal health and neonatal outcomes | Pediatric Research

1 week ago | nature.com | Parvathy Krishnan |Elizabeth Yen

The landscape of cannabis use has changed rapidly, with over 40% of adults aged 19 to 30 years using cannabis in the past year. Of great concern is the rising prevalence in pregnant women, fueled by the legalization and its public perception of safety. However, emerging evidence from animal/in vitro and human studies suggests that prenatal cannabis exposure influence maternal physiology and fetal development, with impact on short- and long-term outcomes. While cannabis exposure is well-known for its impacts on cognitive functioning and neurodevelopment, it also affects other organ systems, leading to long-term cardiovascular, hematologic, gastrointestinal, growth, and endocrine/metabolic dysregulations. This narrative mini-review describes the historical background of cannabis, and provides an overview of how prenatal cannabis exposure affect maternal physiology and fetal development across multiple organ systems. We aim to provide clinicians with a practical understanding of the biological and developmental impact of prenatal cannabis exposure to support evidence-informed counseling during pregnancy and lactation.
TSC22 domain family member 3 links natural killer cells to CD8+ T cell-mediated drug hypersensitivity - Signal Transduction and Targeted Therapy

1 week ago | nature.com | Zhenzhen Wang |Joshua Gardner |Xiaoli Meng

AbstractSevere cutaneous adverse drug reactions (SCARs) are life-threatening diseases, which are associated with human leukocyte antigen (HLA) risk variants. However, the low positive predictive values of HLA variants suggest additional factors influence disease susceptibility. Using dapsone hypersensitivity syndrome (DHS) as a paradigm for SCARs, we show that the DHS patients harbor a sex-related global reduction in blood NK cells, contributing to the higher incidence of reactions in females.
A survey of pathogenic involvement in non-communicable human diseases - Communications Medicine

1 week ago | nature.com | Michael Lape |Daniel J. Schnell |Shannon O’Connor |Nathan Salomonis |Lisa Martin |Leah C. Kottyan

AbstractMany relationships between pathogens and human disease are well-established. However, only a small fraction involve diseases considered non-communicable (NCDs). In this study, we sought to leverage the vast amount of newly available electronic health record data to identify potentially novel pathogen-NCD associations and find additional evidence supporting known associations.