Nature Reviews Immunology

1 day ago | nature.com | Humberto Basilio

What Rina Green calls her “living hell” began with an innocuous backache. By late 2022, two years later, pain flooded her entire body daily and could be so intense that she couldn’t get out of bed. Painkillers and physical therapy offered little relief. She began using a wheelchair. Green has fibromyalgia, a mysterious condition with symptoms of widespread and chronic muscle pain and fatigue. No one knows why people get fibromyalgia, and it is difficult to treat.

2 days ago | nature.com | Xin Li |Huadong Guo |Guodong Cheng |Youhua Ran |Min Feng |Tao Che | +5 more

AbstractAs important components of global commons, environmental changes in polar regions are crucial to the local and global sustainability. However, they have received little attention in the current framework of sustainable development goals (SDGs). This study examines the impacts of climate change in polar regions, emphasizing the interconnectedness of these areas with other parts of the global system.

2 days ago | nature.com | Kirsty Minton

Growing evidence suggests that the interindividual variation in vaccine responses may be due to differences in the gut microbiota. Mouse and human studies have shown that antibiotic exposure can impair antibody responses to certain vaccines. Here, Ryan et al. report the results of a prospective clinical study of immune responses to vaccination after early-life antibiotic exposure using a systems vaccinology approach.

3 days ago | nature.com | Christy Steadman |Eric Small

AbstractMicroalgae remain an important feedstock in the circular bioeconomy. The discovery of new species combined with advanced biotechnology drives optimization of performance predicated on deep knowledge of algal genomics and phenotype. Understanding the contribution of epigenetic processes to algal function provides insight and better approaches for achieving production goals.

3 days ago | nature.com | Susan Allison

IgA nephropathy (IgAN) is a common form of glomerulonephritis. Its pathogenesis has been linked to aberrant O-glycosylation of the IgA1 hinge region, which is thought to underlie the formation of IgA1-containing immune complexes that deposit in glomeruli. New insights suggest that IgA O-glycosylation may also affect additional processes, including mucosal immunity and B cell homing to mucosal and non-mucosal lymphoid tissues.